TISSUE GRAFTS WITH PRE-MADE ATTACHMENT POINTS

• US 20190314132A1
• Filed: 04/11/2019
• Published: 10/17/2019
• Est. Priority Date: 04/12/2018
• Status: Active Grant

• Current Assignee: Axogen Corporation (LecTec Corporation)
• Original Assignee: Axogen Corporation (LecTec Corporation)
• Inventors: Deister, Curt Andrew, Tinnemeyer, Jonathan Andrew, Grayam, Kirk Michael
• Granted Patent: US 11,166,800 B2
• Time in Patent Office: Days
• CPC Class Codes: A61B 17/11 for performing anastomosis; Buttons for anastomosis
• CPC Class Codes: A61B 17/1114 of the digestive tract, e.g. bowels or oesophagus
• CPC Class Codes: A61B 17/1128 of nerves
• CPC Class Codes: A61B 17/1146 of tendons
• CPC Class Codes: A61B 2017/1107 for blood vessels
• CPC Class Codes: A61B 2017/1132 End-to-end connections
• CPC Class Codes: A61B 2090/0807 Indication means
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61F 2/04 Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts A61F2/18, A61F2/20 take precedence; devices, other than stent-grafts, providing patency to, or preventing collapsing of, tubular structures of the body other than stent-grafts, e.g. stents A61F2/82; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95
• CPC Class Codes: A61F 2002/0081 directly machined on the prosthetic surface, e.g. holes, grooves A61F2/30771 takes precedence
• CPC Class Codes: A61F 2002/045 Stomach, intestines
• CPC Class Codes: A61F 2220/0008 Fixation appliances for connecting prostheses to the body
• CPC Class Codes: A61F 2230/0019 rectangular
• CPC Class Codes: A61F 2230/0069 cylindrical
• CPC Class Codes: A61F 2250/0025 differing in roughness
• CPC Class Codes: A61F 2250/0097 Visible markings, e.g. indicia
• CPC Class Codes: A61L 2430/32 for nerve reconstruction
• CPC Class Codes: A61L 27/3804 characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence

Abstract

The present disclosure pertains to membranous tissue grafts comprising one or more pre-made attachment points. The one or more pre-made attachment points may include pre-made markings and/or pre-made suture holes. The membranous tissue grafts can be in the form of a tube. The membranous tissue grafts can also be rectangular in shape and can be used in a nerve repair by wrapping the severed or damaged nerve. In some embodiments, the membranous tissue grafts are suitable for repairing severed nerves that have a short gap or no gap with a gap of less than 5 mm between the severed stumps. Accordingly, methods are provided for repairing a damaged or severed nerve by implanting the membranous tissue grafts on to the damaged or severed nerve.

Claims

1. A membranous tissue graft with one or more pre-made attachment points.

2. The membranous tissue graft of claim 1, having a thickness of between 25 microns and 3 millimeters.

3. The membranous tissue graft of claim 1, comprising a natural material.

4. The membranous tissue graft of claim 3, wherein the natural material is selected from porcine small intestine submucosa, amniotic/chorionic membrane, reconstituted denatured collagen, collagen, elastin, thrombin, fibronectin, starches, poly(amino acid), gelatin, alginate, pectin, fibrin, oxidized cellulose, chitin, chitosan, tropoelastin, hyaluronic acid, fibrin-based materials, collagen-based materials, hyaluronic acid-based materials, glycoprotein-based materials, cellulose-based materials, silks, and combinations thereof.

5. The membranous tissue graft of claim 1, comprising a synthetic material.

6. The membranous tissue graft of claim 5, wherein the synthetic material is selected from silicone, expanded polytetrafluoroethylene (ePTFE), polyethylene tetraphthlate (Dacron), polyurethane aliphatic polyesters, poly(amino acids), poly(propylene fumarate), copoly(ether-esters), polyalkylenes oxalates, polyamides, tyrosine derived polycarbonates, poly(iminocarbonates), polyorthoesters, polyoxaesters, polyamidoesters, polyoxaesters containing amine groups, poly(anhydrides), polyphosphazenes, and blends thereof.

7. The membranous tissue graft of claim 1, comprising one or more bioactive components that facilitate repair of a damaged tissue.

8. The membranous tissue graft of claim 1, wherein the one or more pre-made attachment points include one or more pre-made suture holes.

9. The membranous tissue graft of claim 1, wherein the one or more pre-made attachment points are disposed towards a periphery of the membranous tissue graft.

10. The membranous tissue graft of claim 1, wherein the membranous tissue graft is in the form of a tube and the one or more pre-made attachment points are disposed along edges at two ends of the tube.

11. The membranous tissue graft of claim 1, wherein the membranous tissue graft is rectangular and the one or more pre-made attachment points are disposed along two opposite sides of the rectangular membranous tissue graft and are absent along the other two sides.

12. The membranous tissue graft of claim 1, wherein the one or more pre-made attachment points are disposed along the edge of the membranous tissue graft at a distance from the edge of about 0.5 millimeters to about 10 millimeters.

13. The membranous tissue graft of claim 1, wherein the one or more pre-made attachment points include one or more markings disposed on the membranous tissue graft and configured to increase the visibility of one or more pre-made attachment points.

14. The membranous tissue graft of claim 13, wherein the membranous tissue graft is in the form of a tube and the one or more markings are disposed along edges at two ends of the tube.

15. The membranous tissue graft of claim 13, wherein the membranous tissue graft is rectangular and the one or more markings are disposed along two opposite sides of the rectangular membranous tissue graft and are absent along the other two sides.

16. The membranous tissue graft claim 13, wherein the one or more markings are disposed along the edge of the tissue graft at a distance from the edge of about 0.5 millimeters to about 10 millimeters.

17. The membranous tissue graft of claim 13, wherein the one or more markings indicate an orientation of the membranous tissue graft.

18. The membranous tissue graft of claim 13, wherein the one or more markings are positioned to assist a user in placement of tissue at a measured distance within the membranous tissue graft.

19. The membranous tissue graft of claim 18, wherein the one or more markings facilitate placement of multiple tissue ends at a measured distance from one another.

20. The membranous tissue graft of claim 1, wherein the one or more pre-made attachment points include one or more pre-made suture holes and one or more markings.

21. A method of repairing a damaged and/or severed nerve, comprising implanting a membranous tissue graft comprising one or more pre-made attachment points to the damaged and/or severed nerve.

22. The method of claim 21, wherein the damaged and/or severed nerve has a gap in the range of about 0 millimeters to about 5 millimeters.