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AMLODIPINE FORMULATIONS

  • US 20190314279A1
  • Filed: 04/11/2019
  • Published: 10/17/2019
  • Est. Priority Date: 04/11/2018
  • Status: Active Grant
First Claim
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1. A suspension comprising amlodipine benzoate particles having a D50 value between about 5 μ

  • m and about 40 μ

    m, the suspension made by the process comprising;

    (i) providing an aqueous mixture of an amlodipine salt that is more soluble in aqueous media than amlodipine benzoate;

    (ii) adding sodium benzoate to the aqueous mixture to form a first mixture; and

    (iii) subjecting the first mixture to ultrasonic agitation thereby forming a second mixture comprising amlodipine benzoate.

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