POROUS POLYMER MICROSPHERES FOR PREVENTING OR TREATING SOFT TISSUE DISEASES AND METHOD FOR MANUFACTURING THE SAME
First Claim
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1. Porous polymer microspheres for preventing or treating soft tissue diseases comprising:
- a biodegradable polymer scaffold having a three-dimensional network structure in which pores having a size of 5 to 100 μ
m are connected to one another; and
a drug for treating soft tissue diseases incorporated in the network structure of the biodegradable polymer scaffold.
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Abstract
Disclosed are porous polymer microspheres for preventing or treating soft tissue diseases including a biodegradable polymer scaffold having a three-dimensional network structure in which pores having a size of 5 to 100 μm are connected to one another, and a drug for treating soft tissue diseases incorporated in the network structure of the biodegradable polymer scaffold.
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23 Claims
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1. Porous polymer microspheres for preventing or treating soft tissue diseases comprising:
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a biodegradable polymer scaffold having a three-dimensional network structure in which pores having a size of 5 to 100 μ
m are connected to one another; anda drug for treating soft tissue diseases incorporated in the network structure of the biodegradable polymer scaffold. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method for manufacturing porous polymer microspheres for preventing or treating soft tissue diseases comprising:
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1) dissolving a biocompatible polymer and a drug for treating soft tissue diseases in an organic solvent to prepare a polymer solution; 2) homogenizing the polymer solution and an aqueous gelatin solution to prepare an emulsion; 3) pouring the emulsion as a discontinuous phase and a polyvinyl alcohol solution as a continuous phase into a fluidic device to produce polymer microspheres including the biocompatible polymer, the drug and gelatin; and 4) stirring the polymer microspheres in 38-50°
C. water to release the gelatin from the polymer microspheres. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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Specification