Method For The Management Of Cancer And Cancer Treatment-Related Comorbidities

• US 20190314441A1
• Filed: 06/26/2019
• Published: 10/17/2019
• Est. Priority Date: 11/08/2013
• Status: Abandoned Application

• Current Assignee: Legacy Healthcare Ltd.
• Original Assignee: Legacy Healthcare Ltd.
• Inventors: HARTI, Saad, LIU, JiaWei
• Application Number:
  US16/453,379
• Publication Number:
  US 20190314441A1
• Time in Patent Office: Days
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/352 condensed with carbocyclic rings, e.g. methantheline cannabinoids A61K31/658
• CPC Class Codes: A61K 36/18 Magnoliophyta (angiosperms)
• CPC Class Codes: A61K 36/185 Magnoliopsida (dicotyledons)
• CPC Class Codes: A61K 36/752 Citrus, e.g. lime, orange or lemon
• CPC Class Codes: A61K 36/77 Sapindaceae (Soapberry family), e.g. lychee or soapberry
• CPC Class Codes: A61K 36/88 Liliopsida (monocotyledons)
• CPC Class Codes: A61K 36/8962 Allium, e.g. garden onion, leek, garlic or chives
• CPC Class Codes: A61P 1/08 for nausea, cinetosis or vertigo; Antiemetics
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 21/00 Drugs for disorders of the muscular or neuromuscular system
• CPC Class Codes: A61P 25/04 Centrally acting analgesics, e.g. opioids
• CPC Class Codes: A61P 25/24 Antidepressants
• CPC Class Codes: A61P 3/02 Nutrients, e.g. vitamins, minerals
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 7/06 Antianaemics

Abstract

A method for the management of cancer and treatment of cancer comorbidities, including but not limited to cancer-related fatigue, cachexia, anorexia, pain, anemia, asthenia, depression, muscle weakness, nausea, vomiting, skin, and skin appendages adverse reactions; the method including the administration by the conventional and non-conventional oral, topical, parenteral routes and intra-tumoral injection, or in combination thereof, or the administration as adjuvant potentiator in other therapies using the forenamed routes, of a composition containing as active ingredient an extract of Allium species, which contains querceting, an extract of Citrus species and an extract of Pauffinia species and an extract of Theobroma species.

Claims

1. A method for managing cancer and for treating at least one cancer comorbidity selected from the group consisting of cachexia, anorexia, pain, anemia, asthenia, depression, muscle weakness, nausea, vomiting, adverse skin reactions, adverse skin appendages reactions, and a combination thereof in a subject in need thereof, the method comprising:

administering to the subject, by an oral route, a topical route, a parenteral route, an intra-tumoral injection, or a combination thereof, a composition comprising as active ingredients an extract of Allium species comprising quercetin, an extract of Citrus species, an extract of Pauffinia species, and an extract of Theobroma species.

2. The method according to claim 1, wherein the composition contains the extract of the Allium species comprising quercetin, the extract of the Citrus species, an atomized extract of the Pauffinia species and an atomized extract of the Theobroma species.

3. The method according to claim 1, wherein the composition comprises:

from 30% to 93% by weight of the extract of the Allium species comprising quercetin,

from 3% to 33% by weight of the extract of the Citrus species,

from 0.10% to 2.5% by weight of the atomized extract of the Paullinia species, and

from 0.10% to 2.5% by weight of the atomized extract of the Theobroma species,

wherein the percentages are based on the total weight of the four active ingredients.

4. The method according to claim 1, wherein the at least one cancer comorbidity comprises pain, depression, muscle weakness, adverse skin reactions, adverse skin appendages reactions, or a combination thereof.

5. The method according to claim 1, wherein the extract of Allium species is an extract of Allium cepa.

6. The method according to claim 1, wherein the extract of Citrus species is an extract of Citrus lemon.

7. The method according to claim 1, wherein the extract of Pauffinia species is an extract of Pauffinia cupana.

8. The method according to claim 1, wherein the extract of Theobroma species is an extract of Theobroma cacao.

9. The method according to claim 1, wherein the composition comprises:

approximately 87% by weight of an extract of Allium cepa comprising quercetin;

approximately 12% by weight of an extract of Citrus lemon;

approximately 0.5% by weight of an extract of Pauffinia cupana; and

approximately 0.5% by weight of an extract of Theobroma cacao,

wherein the percentages are based on the total weight of the four active ingredients.

10. A method for managing cancer and for treating at least one cancer comorbidity in a subject in need thereof, the method comprising:

administering to the subject a composition comprising an extract of Allium species, an extract of Citrus species, an extract of Pauffinia species, and an extract of Theobroma species.

11. The method according to claim 10, wherein the extract of Allium species comprises quercetin.

12. The method according to claim 10, wherein the administering is performed orally, topically, or parenterally.

13. The method according to claim 10, wherein at least one of the extract of Pauffinia species or the extract of Theobroma species is atomized.

14. The method according to claim 10, wherein the composition comprises:

from 30% to 93% by weight of the extract of the Allium species;

from 3% to 33% by weight of the extract of the Citrus species;

from 0.10% to 2.5% by weight of the extract of the Pauffinia species; and

from 0.10% to 2.5% by weight of the extract of the Theobroma species,

wherein the percentages are based on the total weight of the extract of Allium cepa, the extract of Citrus lemon, the extract of Pauffinia cupana, and the extract of Theobroma cacao.

15. The method according to claim 10, wherein the composition consists of the extract of Allium species, the extract of Citrus species, the extract of Pauffinia species, and the extract of Theobroma species.

16. The method according to claim 10, wherein the at least one cancer comorbidity is cancer-related fatigue, cachexia, anorexia, pain, anemia, asthenia, depression, muscle weakness, nausea, vomiting, adverse skin reactions, adverse skin appendages reactions, or a combination thereof.

17. A method for managing cancer and for treating at least one cancer comorbidity in a subject in need thereof, the method comprising:

administering to the subject a composition comprising;

from 30% to 93% by weight of an extract of Allium cepa comprising quercetin;

from 3% to 33% by weight of an extract of Citrus lemon;

from 0.10% to 2.5% by weight of an extract of Pauffinia cupana; and

from 0.10% to 2.5% by weight of an extract of Theobroma cacao,

wherein the percentages are based on the total weight of the extract of Allium cepa, the extract of Citrus lemon, the extract of Pauffinia cupana, and the extract of Theobroma cacao.

18. The method according to claim 17, wherein the composition comprises:

approximately 87% by weight of the extract of Allium cepa comprising quercetin;

approximately 12% by weight of the extract of Citrus lemon;

approximately 0.5% by weight of the extract of Pauffinia cupana; and

approximately 0.5% by weight of the extract of Theobroma cacao.

19. The method according to claim 17, wherein the composition consists of the extract of Allium cepa comprising quercetin, the extract of Citrus lemon, the extract of Pauffinia cupana;

and the extract of Theobroma cacao.

20. The method according to claim 17, wherein the administering comprises administering the composition to the subject daily for at least 6 months.