DELIVERY SYSTEM FOR INTENSITY MODULATED HIGH DOSE RATE BRACHYTHERAPY WITH INTERMEDIATE ENERGY BRACHYTHERAPY ISOTOPES

• US 20190314643A1
• Filed: 12/20/2017
• Published: 10/17/2019
• Est. Priority Date: 12/21/2016
• Status: Active Grant

• Current Assignee: McGill University
• Original Assignee: McGill University
• Inventors: ENGER, Shirin Abbasi Nejad, FAMULARI, Gabriel
• Granted Patent: US 11,324,966 B2
• Time in Patent Office: Days
• CPC Class Codes: A61N 2005/1008 Apparatus for temporary insertion of sources, e.g. afterloaders
• CPC Class Codes: A61N 2005/1012 Templates or grids for guiding the introduction of sources
• CPC Class Codes: A61N 2005/1094 Shielding, protecting against radiation
• CPC Class Codes: A61N 5/1007 Arrangements or means for the introduction of sources into the body
• CPC Class Codes: A61N 5/1027 Interstitial radiation therapy

Abstract

A delivery system and method for radiation shielded brachytherapy comprises a drive assembly, and a plurality of shield assemblies, pivotally mounted to the drive assembly, each having a tubular body defining an outer surface and a bore longitudinally extending between opposite ends of the tubular body. Each of the shield assemblies comprises radiation shielding material extending about a circumferential portion of the tubular body and disposed between the outer surface and the cavity. An interlocking system is operatively mounted to the rotating assembly, and engages a group of the plurality of shield assemblies. The interlocking system is configured for transmitting a rotational input received from a driving mechanism to the group of shield assemblies, for synchronously rotating each shield assembly of the group about their respective longitudinal axis.

Claims

1. A delivery system for radiation shielded brachytherapy, the delivery system being adapted to receive an input of radionuclide from an afterloader, the delivery system comprising:

a drive assembly having a drive mechanism and connectors rotatable by the drive mechanism, each of the connectors having one of two or more shield assemblies detachably coupled thereto for rotation about a longitudinal axis of the respective shield assembly, each of the shield assemblies including a needle having a tubular body defining an outer surface and a bore longitudinally extending between opposite ends of the tubular body, the bore being adapted to receive therethrough the input of radionuclide for delivery to a target site, a radiation shielding material extending about a circumferential portion of the tubular body of the needle and disposed radially outwardly of the bore; and

an interlocking system operatively mounted to the drive assembly, the interlocking system engaging a group of the two or more shield assemblies via their respective connectors, wherein the interlocking system transmits a rotational input received from the driving mechanism to the group of shield assemblies and synchronously rotates each of the shield assemblies of the group about its respective longitudinal axis.

2. The delivery system of claim 1, wherein the interlocking system comprises a fixed panel and a plurality of said connectors extending therethrough, the interlocking system comprising a moving panel operatively coupled to a group of said connectors engaging the group of the plurality of shield assemblies.

3. The delivery system of claim 2, wherein each connector defines a transmitter and a coupler, the transmitter being received within a hole defined through the moving panel, an axis of rotation of the coupler is parallel but non-coaxial with an axis of rotation of the transmitter.

4. The delivery system of claim 3, wherein the moving panel is received within a recess of the fixed panel, the recess having a footprint greater than a footprint of the moving panel.

5. The delivery system of claim 1, to wherein the driving mechanism comprises at least one electric motor operatively mounted to the rotating assembly.

6. The delivery system of claim 1, wherein each of the shield assemblies is operatively coupled to the drive assembly through a link assembly, the link assembly interconnecting a connector of the drive assembly and one of the shield assemblies.

7. The delivery system of claim 6, wherein the link assembly comprises a flexible luer.

8. The delivery system of claim 1, wherein the shield assemblies are connected to the drive assembly by respective flexible link assemblies, the longitudinal axis of each of the shield assemblies defines an angle with the respective connector of the rotating assembly, wherein each of the flexible link assemblies is independently bendable such that said angles of each of the shield assemblies is independently modifiable.

9. The delivery system of claim 1, wherein the interlocking system comprises a plurality of stages, each stage controlling a given group of the plurality of shield assemblies.

10. The delivery system of claim 1, wherein the radiation shielding material is non-uniformly circumferentially distributed around the bore.

11. The delivery system of claim 1, wherein the radiation shielding material extends longitudinally between the opposed ends of the tubular body.

12. A method for directing radiation to target site of a tumour in brachytherapy, comprising:

inserting a group of radiation shield assemblies proximate the tumour, the group of radiation shield assemblies each having a tubular body with a bore longitudinally extending therethrough along a longitudinal axis, a radiation shielding material extending about a circumferential portion of the tubular body; and

synchronously rotating each of the radiation shield assemblies of the group about the respective longitudinal axis until the circumferential portion of at least one radiation shield assembly of the group is disposed on an opposite side of the tubular body from the target site of the tumour; and

providing an input of radionuclide from an afterloader through the bore of the tubular body of said at least one shield assembly and directing the radiation from the input of radionuclide toward the target site of the tumour and restricting the radiation to the target site.

14. The method of claim 12, further comprising independently rotating another group of the radiation shield assemblies with the driving mechanism until a circumferential portion comprising radiation shielding material of at least one shield assembly of the other group of the radiation shield assemblies faces away from the target site, and directing radiation received from a second input of the radionuclide toward the target site.

15. The method of claim 12, further comprising removing the radionuclide from the at least one radiation shield assembly before synchronously rotating said group until a circumferential portion comprising radiation shielding material of another shield assembly of said group faces away from the target site.

16. The method of claim 12, further comprising circumscribing the target site with the plurality of radiation shield assemblies.

17. The method of claim 16, further comprising synchronously rotating the radiation shield assemblies about their respective longitudinal axis until the circumferential portion having radiation shielding material of all of the radiation shield assemblies of said group faces away from the target site.

18. The method of claim 12, further comprising providing a drive assembly having a drive mechanism and connectors rotatable by the drive mechanism, and operatively coupling the radiation shield assemblies with the connectors of the drive mechanism using a link assembly.

19. The method of claim 18, further comprising absorbing any angular mismatch between the radiation shield assemblies and the connectors of the drive assembly using a flexible element in the link assembly.

20. The method of claim 19, further comprising independently bending each of the flexible elements of the link assembly to independently modify an angle between the longitudinal axis of the radiation shield assemblies and an axis of each respective connector of the drive assembly.

21. The method of claim 12, further comprising independently controlling each of two or more groups of the radiation shield assemblies.

13. (canceled)