MICROFLUIDIC METERING AND DELIVERY SYSTEM
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Accused Products
Abstract
This invention provides devices, systems, and methods for performing point-of-care, analysis, including multiplexed analysis, of a biological fluid analyte, such as blood. The invention includes a cartridge for collecting the biological fluid analyte. The cartridge is configured to be inserted into an assay reader, in which one or more assay reactions may be performed. The assay reader is designed to read and report the results of the one or more assay reactions.
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21 Claims
- 1. (canceled)
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2. An analyte collection device, comprising:
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a metering stack comprising a first channel, wherein the first channel comprises a porous or mesh material and one or more venting holes; an assay stack comprising one or more assay elements, at least one of the assay pads comprising a reagent for performing an assay; and a spacing element positioning the metering stack and the assay stack apart from each other when in an uncompressed state and allowing the metering stack and the assay stack to come into contact when in a compressed state, wherein the porous or mesh material permits flow from the metering stack to the assay stack when in the compressed state. - View Dependent Claims (3, 4, 5, 6, 7, 8, 10, 11, 12, 13)
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14. A method of fabricating a cartridge, the method comprising:
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obtaining a first layer comprising (1) a first material with a channel formed therein, wherein the channel comprises at least one venting hole, and (2) a porous or mesh material attached on a bottom surface of the first material; obtaining a second layer comprising one or more assay elements, at least one of the assay elements comprising a porous material capable of absorbing analyte, and a reagent for performing an assay; obtaining a spacing mechanism; and combining the first layer, the spacing mechanism, and second layer in a housing such that the spacing mechanism separates the first layer and the second layer when in an uncompressed state, and the channel is aligned with the two or more assay elements in a direction perpendicular to the first layer. - View Dependent Claims (15, 16, 17)
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18. A cartridge for collecting blood for testing, the cartridge comprising:
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a metering stack configured to receive and distribute the blood along a first channel, wherein the first channel has a portion that comprises a porous or mesh material and one or more venting holes; an assay stack comprising one or more assay pads, at least one of the one or more assay pads comprising a reagent for performing an assay on the blood or a portion thereof; and a separation mechanism preventing fluid communication between the metering stack and the assay stack when in an uncompressed state and allowing the metering stack and the assay stack to come into fluid communication when in a compressed state, wherein the porous or mesh material permits the blood or a portion thereof to flow from the metering stack to the assay stack when in the compressed state. - View Dependent Claims (19, 20, 21)
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Specification