CYCLOPROPANAMINE COMPOUND AND USE THEREOF
0 Assignments
0 Petitions
Accused Products
Abstract
The present invention provides a compound having a lysine-specific demethylase-1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for schizophrenia, developmental disorders, particularly diseases having intellectual disability (e.g., autistic spectrum disorders, Rett syndrome, Down'"'"'s syndrome, Kabuki syndrome, fragile X syndrome, Kleefstra syndrome, neurofibromatosis type 1, Noonan syndrome, tuberous sclerosis), neurodegenerative diseases (e.g., Alzheimer'"'"'s disease, Parkinson'"'"'s disease, spinocerebellar degeneration (e.g., dentatorubural pallidoluysian atrophy) and Huntington'"'"'s disease), epilepsy (e.g., Dravet syndrome) or drug dependence, and the like. A compound represented by the formula
wherein each symbol is as defined in the present specification, or a salt thereof.
-
Citations
21 Claims
- 1. A compound represented by the formula
-
11-13. -13. (canceled)
-
17-20. -20. (canceled)
-
21. 5-((1R,2R)-2-((Cyclobutylmethyl)amino)cyclopropyl)-N-(tetrahydro-2H-pyran-4-yl)thiophene-3-carboxamide or a salt thereof.
Specification