RUTAECARPINE ANALOGS AND APPLICATIONS THEREOF
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Abstract
The present invention provides RUT analogs with various biological activities. In particular, the biological activities comprise anti-inflammatory activity, vasodilator effects, migration/invasion-suppressive activities, ability against damage due to remodeling between the epithelium and endothelium, collagen deposition and cardiac fibrosis suppress. Snail protein inhibitory effect, etc., which may improve cardiac, vasodilation, and lung functions. The RUT analogs disclosed herein also exhibit a lower cytotoxicity comparing to RUT.
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Citations
17 Claims
- 1. A compound having the following Formula (I),
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16. A compound of 10-fluoro-2-methoxyrutaecarpine (F-RUT).
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17. A compound of 10-fluoro-2,3-dimethoxyrutaecarpine.
Specification