NOVEL PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST ESOPHAGEAL CANCER AND OTHER CANCERS
First Claim
1. A method of treating a patient who has a cancer overexpressing NUP155 polypeptide comprising the amino acid sequence of SEQ ID NO:
- 80, comprising administering to said patient a composition comprising a population of activated T cells that kill the cancer cells,wherein the activated T cells are cytotoxic T cells produced by contacting T cells with an antigen presenting cell that presents a peptide consisting of the amino acid sequence of SEQ ID NO;
80 in a complex with an MHC class I molecule on the surface of the antigen presenting cell in vitro, for a period of time sufficient to activate said T cell,wherein said cancer is selected from the group consisting of esophageal cancer, lung cancer, urinary bladder cancer, head and neck cancer, ovarian cancer, melanoma, uterine cancer, hepatocellular cancer, renal cell cancer, brain cancer, colorectal cancer, breast cancer, gastric cancer, pancreatic cancer, gallbladder cancer, bile duct cancer, prostate cancer, and leukemia.
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Accused Products
Abstract
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
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20 Claims
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1. A method of treating a patient who has a cancer overexpressing NUP155 polypeptide comprising the amino acid sequence of SEQ ID NO:
- 80, comprising administering to said patient a composition comprising a population of activated T cells that kill the cancer cells,
wherein the activated T cells are cytotoxic T cells produced by contacting T cells with an antigen presenting cell that presents a peptide consisting of the amino acid sequence of SEQ ID NO;
80 in a complex with an MHC class I molecule on the surface of the antigen presenting cell in vitro, for a period of time sufficient to activate said T cell,wherein said cancer is selected from the group consisting of esophageal cancer, lung cancer, urinary bladder cancer, head and neck cancer, ovarian cancer, melanoma, uterine cancer, hepatocellular cancer, renal cell cancer, brain cancer, colorectal cancer, breast cancer, gastric cancer, pancreatic cancer, gallbladder cancer, bile duct cancer, prostate cancer, and leukemia. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
- 80, comprising administering to said patient a composition comprising a population of activated T cells that kill the cancer cells,
Specification