ANTIBODY AGENTS SPECIFIC FOR HUMAN CD19 AND USES THEREOF
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Abstract
Described herein are human antibody agents and multi-specific binding agents that specifically bind human CD 19, in particular, native human CD 19. Also provided herein are methods of using the same or compositions thereof for the detection, prevention and/or therapeutic treatment of diseases characterized by CD 19 expression, in particular, B cell lymphomas and leukemias.
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Citations
61 Claims
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1-41. -41. (canceled)
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42. An antibody agent, or a variant thereof, that specifically binds human CD19, wherein the antibody agent comprises a heavy chain CDR1 (HC-CDR1), a heavy chain CDR2 (HC-CDR2) and a heavy chain CDR3 (HC-CDR3), and a light chain CDR1 (LC-CDR1), a light chain CDR2 (LC-CDR2) and a light chain CDR3 (LC-CDR3), wherein
(i) the HC-CDR1 comprises the sequence of GYSFTSYW (SEQ ID NO: - 115) or a sequence having one or more amino acid substitutions relative to the sequence of SEQ ID NO;
115;(ii) the HC-CDR2 comprises the sequence of IYPGDSDT (SEQ ID NO;
116) or a sequence having one or more amino acid substitutions relative to the sequence of SEQ ID NO;
116;(iii) the HC-CDR3 comprises the sequence of ARQVWGWQGGMYPRSNWWYNMDS (SEQ ID NO;
117) or a sequence having one or more amino acid substitutions relative to the sequence of SEQ ID NO;
117;(iv) the LC-CDR1 comprises the sequence of NIGSKS (SEQ ID NO;
223) or a sequence having one or more amino acid substitutions relative to the sequence of SEQ ID NO;
223;(v) the LC-CDR2 comprises the sequence of DDS (SEQ ID NO;
224) or a sequence having one or more amino acid substitutions relative to the sequence of SEQ ID NO;
224; and(vi) the LC-CDR3 comprises the sequence of QVWDSSSDYVV (SEQ ID NO;
225) or a sequence having one or more amino acid substitutions relative to the sequence of SEQ ID NO;
225. - View Dependent Claims (43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61)
- 115) or a sequence having one or more amino acid substitutions relative to the sequence of SEQ ID NO;
Specification