SYSTEM AND METHOD FOR VOLATILE ORGANIC COMPOUND DETECTION

• US 20190317079A1
• Filed: 10/16/2018
• Published: 10/17/2019
• Est. Priority Date: 10/16/2017
• Status: Abandoned Application

• Current Assignee: Sightline Innovation, Inc.
• Original Assignee: Sightline Innovation, Inc.
• Inventors: TRENHOLM, Wallace, ALEXIUK, Mark, DANG, Hieu, MALEKTAJI, Siavash
• Application Number:
  US16/161,458
• Publication Number:
  US 20190317079A1
• Time in Patent Office: Days
• CPC Class Codes: G01N 2021/7793 Sensor comprising plural indicators
• CPC Class Codes: G01N 21/31 Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry G01N21/72 takes precedence
• CPC Class Codes: G01N 21/783 for analysing gases
• CPC Class Codes: G01N 33/52 Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements immunological elements G01N33/54386; involving labelled immunochemicals G01N33/58; for haemoglobin or occult blood G01N33/72
• CPC Class Codes: G06F 18/24143 Distances to neighbourhood prototypes, e.g. restricted Coulomb energy networks [RCEN]
• CPC Class Codes: G06N 20/00 Machine learning
• CPC Class Codes: G06N 20/20 Ensemble learning
• CPC Class Codes: G06N 3/044 Recurrent networks, e.g. Hopfield networks
• CPC Class Codes: G06N 3/084 Backpropagation, e.g. using gradient descent
• CPC Class Codes: G06T 2207/10024 Color image
• CPC Class Codes: G06T 2207/20224 Image subtraction
• CPC Class Codes: G06T 2207/30072 Microarray; Biochip, DNA array; Well plate
• CPC Class Codes: G06T 7/0002 Inspection of images, e.g. flaw detection
• CPC Class Codes: G06T 7/0012 Biomedical image inspection
• CPC Class Codes: G06V 10/48 by mapping characteristic values of the pattern into a parameter space, e.g. Hough transformation
• CPC Class Codes: G06V 10/56 relating to colour
• CPC Class Codes: G06V 10/764 using classification, e.g. of video objects
• CPC Class Codes: G06V 10/7715 Feature extraction, e.g. by transforming the feature space, e.g. multi-dimensional scaling [MDS]; Mappings, e.g. subspace methods
• CPC Class Codes: G06V 10/82 using neural networks
• CPC Class Codes: G16C 20/20 Identification of molecular entities, parts thereof or of chemical compositions
• CPC Class Codes: G16C 20/70 : Machine learning, data mining or chemometrics

Abstract

A system and method for identifying an analyte based on the presence of at least one volatile organic compound (“VOC”) in the analyte. The method includes: receiving image data from a sensor array, the sensor array having been exposed to the analyte, the sensor array including at least one sensor configured to respond to the presence of the at least one VOC in the analyte; processing the image data to derive one or more input image features; and using a trained machine learning classification technique, detecting the at least one VOC and classifying the analyte based on the one or more input image features, the machine learning classification technique trained using one or more reference images of known analytes.

Claims

1. A method of identifying an analyte based on the presence of at least one volatile organic compound (“

VOC”

) in the analyte, comprising;

receiving image data from a sensor array after the sensor array has been exposed to the analyte, the sensor array comprising at least one sensor configured to respond to the presence of the at least one VOC in the analyte;

processing the image data to derive one or more input image features; and

using a trained machine learning classification technique, detecting the at least one VOC and classifying the analyte based on the one or more input image features, the machine learning classification technique trained using one or more reference images of known analytes.

2. The method of claim 1, wherein the sensor array comprises a colorimetric sensor array of a plurality of colorimetric sensors, each colorimetric sensor changing in color or in color intensity when exposed to the VOC present in the analyte.

3. The method of claim 2, wherein receiving the image data comprises repeatedly receiving image data of the sensor array at a series of time intervals.

4. The method of claim 3, wherein processing the image data to derive the one or more input image features comprises comparing image data in each of the images in the image series to the one of the reference images to generate comparison image data comprising color differences, the input image features comprising the comparison image data.

5. The method of claim 4, wherein, for each image in the image series, processing the image data comprises:

performing edge detection on the image data;

performing a Hough circle transform on the image data;

detecting an image rotation angle; and

where there is a previous image in the image series, aligning the image with the previous image.

6. The method of claim 2, wherein processing the image data comprises applying adaptive thresholding to produce a binarized image of the image data.

7. The method of claim 6, wherein processing the image data further comprises performing a Hough Circle Transform to detect a blob circle on the binarized image and to segment color blobs on the binarized image.

8. The method of claim 7, wherein processing the image data further comprises predicting missing a missing color blob using geometric interpolation.

9. The method of claim 2, wherein the one or more input image features comprise color features comprising at least one of global mean, global mode, inner mean, and inner mode.

10. The method of claim 2, wherein the one or more input image feature comprises textural features comprising at least one of co-occurrence matrix, angular second moment, contrast, correlation, entropy, Hellinger Distance, and Hausdorff Distance.

11. The method of claim 2, wherein the machine learning classification technique comprises one of support vector machines, stacked auto encoders, multi-layer perceptrons, recurrent neural networks, or deep learning neural networks.

12. A system for identifying an analyte based on the presence of at least one volatile organic compound (“

VOC”

) in the analyte, the system in communication with an image acquisition device, the system comprising one or more processors in communication with a memory, the one or more processors configured to execute;

an image processing module to;

receive image data from a sensor array on the image acquisition device after the sensor array has been exposed to the analyte, the sensor array comprising at least one sensor configured to respond to the presence of the at least one VOC in the analyte; and

process the image data to derive one or more input image features; and

a classification module to, using a trained machine learning classification technique, classify the analyte based on the one or more input image features, the machine learning classification technique trained using one or more reference images of known analytes.

13. The system of claim 12, wherein the sensor array comprises a colorimetric sensor array of a plurality of colorimetric sensors, each colorimetric sensor changing in color or in color intensity when exposed to the VOC present in the analyte.

14. The system of claim 13, wherein receiving the image data comprises repeatedly receiving image data of the sensor array at a series of time intervals.

15. The system of claim 14, wherein processing the image data to derive the one or more input image features comprises comparing image data in each of the images in the image series to the one of the reference images to generate comparison image data comprising color differences, the input image features comprising the comparison image data.

16. The system of claim 13, wherein processing the image data comprises applying adaptive thresholding to produce a binarized image of the image data.

17. The system of claim 16, wherein processing the image data further comprises performing a Hough Circle Transform to detect a blob circle on the binarized image and to segment color blobs on the binarized image.

18. The system of claim 13, wherein the one or more input image features comprise color features comprising at least one of global mean, global mode, inner mean, and inner mode.

19. The system of claim 13, wherein the one or more input image features comprise textural features comprising at least one of co-occurrence matrix, angular second moment, contrast, correlation, entropy, Hellinger Distance, and Hausdorff Distance.

20. The system of claim 13, wherein the machine learning classification technique comprises one of support vector machines, stacked auto encoders, multi-layer perceptrons, recurrent neural networks, or deep learning neural networks.