SYNCHRONIZATION DEVICES AND METHODS FOR SYNCHRONIZING IMAGING SYSTEMS AND STIMULATION SYSTEMS

• US 20190317170A1
• Filed: 12/12/2017
• Published: 10/17/2019
• Est. Priority Date: 12/12/2016
• Status: Active Grant

• Current Assignee: Lvis Corporation
• Original Assignee: Lvis Corporation
• Inventors: MADSEN, Michael, FANG, Zhongnan, LEE, Jin Hyung
• Granted Patent: US 10,942,238 B2
• Time in Patent Office: Days
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/4064 Evaluating the brain A61B5/031, A61B5/369, A61B5/14553 take precedence
• CPC Class Codes: A61B 5/7292 Prospective gating, i.e. predicting the occurrence of a physiological event for use as a synchronisation signal
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/08 Arrangements or circuits for monitoring, protecting, controlling or indicating for external stimulators A61N1/3603; for implantable neurostimulators A61N1/36128; for heart stimulators A61N1/37; for defibrillators A61N1/3925
• CPC Class Codes: A61N 1/36128 Control systems
• CPC Class Codes: G01R 33/28 Details of apparatus provided for in groups G01R33/44 - G01R33/64
• CPC Class Codes: G01R 33/4806 Functional imaging of brain activation
• CPC Class Codes: G01R 33/5613 Generating steady state signals, e.g. low flip angle sequences [FLASH]
• CPC Class Codes: G01R 33/5676 Gating or triggering based on an MR signal, e.g. involving one or more navigator echoes for motion monitoring and correction

Abstract

Examples described herein may provide for pre-triggering imaging scans (e.g. fMRI scans) using an electronic timer synchronized to a stimulation system.

Claims

1. A method comprising:

initiating a functional magnetic resonance imaging scan (an fMRI scan) of a patient with a functional magnetic resonance imaging system (an fMRI system) at an initiation time prior to a stimulation time when the patient is stimulated by an implanted stimulator, wherein the implanted stimulator is configured to stimulate the patient every period, and wherein a duration between the initiation time and the stimulation time is sufficient for the fMRI system to achieve a steady state; and

initiating another fMRI scan of the patient one period after the initiation time.

2. The method of claim 1 further comprising performing dummy scans with the fMRI system at a time between the initiation time and the stimulation time.

3. The method of claim 1, wherein the one period after the initiation time is prior to a second stimulation time when the patient is again stimulated by the implanted stimulator.

4. The method of claim 3 further comprising performing dummy scans with the fMRI system at a time between the one period after the initiation time and the second stimulation time.

5. The method of claim 1, further comprising receiving indication of an initial stimulation time from the implanted stimulator and calculating, using an electronic timer, the initiation time at least in part by adding the period to the initial stimulation time and subtracting a settling time during which the fMRI is configured to achieve the steady state.

6. The method of claim 5, further comprising providing a trigger signal from the electronic timer to the fMRI system at the initiation time.

7. The method of claim 6, further comprising counting, with the electronic timer, the period, and providing another trigger signal from the electronic timer to the fMRI system at the one period after the initiation time.

8. A device comprising:

an input configured to receive an indication of stimulation initiation from an implanted stimulator, the implanted stimulator configured to provide stimulation every period;

synchronization circuitry configured to calculate an initial time of scan initiation at least in part by adding the period to a time the indication of stimulation initiation was received and subtracting a settling time during which a scanning system is configured to attain steady state; and

trigger circuitry configured to provide a trigger to the scanning system to initiate a scan at the initial time.

9. The device of claim 8, wherein the synchronization circuitry is further configured to calculate a next time of scan initiation at least in part by adding the period to the initial time;

and

wherein the trigger circuitry is further configured to provide another trigger to the scanning system at the nest time.

10. The device of claim 8, wherein the synchronization circuitry is provided in a field programmable gate array (FPGA) device.

11. The device of claim 8, further comprising a display configured to display a remaining time until the initial time.

12. The device of claim 8, wherein the device is configured to implement a state machine, and wherein a first state comprises a standby state, the device further comprising a second input configured to receive an indication to exit standby state, and wherein the synchronization circuitry is configured to calculate the initial time responsive to receipt of the indication of stimulation when the device has exited the standby state.

13. The device of claim 12, wherein the second input comprises a user accessible switch.

14. The device of claim 12, wherein a second state comprises an initial trigger calculation state during which the synchronization circuitry is configured to calculate the initial time, and wherein a third state comprises a repetitive trigger state during which the synchronization circuitry is configured to calculate next trigger times by adding the period to a previous trigger time.

15. The device of claim 8, further comprising a memory configured to store the period.

16. A system comprising:

a functional magnetic resonance imaging system (an fMRI system), the fMRI system configured to provide fMRI scans of a patient;

a stimulation system configured to stimulate the patient; and

a synchronization device, the synchronization device configured to trigger the fMRI system to initiate at least one of the fMRI scans at a time prior to simulation of the patient by the stimulation system, such that the fMRI system attains steady state prior to the stimulation of the patient by the stimulation system.

17. The system of claim 16, wherein the fMRI system is configured to provide at least one dummy scan prior to attaining the steady state.

18. The system of claim 16, wherein the synchronization device is configured to receive an initial indication of stimulation from the stimulation system, and wherein the synchronization device is configured to determine a first trigger time by adding a period of the simulations provided by the stimulation system to a time of the initial indication and subtracting a settling time during which the fMRI system is configured to attain the steady state.

19. The system of claim 18, wherein the synchronization device is configured to provide a trigger signal to the fMRI system to initiate a scan at the first trigger time.

20. The system of claim 18, wherein the synchronization device is configured to determine subsequent trigger times by adding multiples of the period to the first trigger time.

21. The system of claim 20, wherein the synchronization device is configured to provide trigger signals to the fMRI system to initiate scans at the subsequent trigger times.