STROKE, CONCUSSION, AND COGNITIVE DYSFUNCTION DIAGNOSTIC METHOD AND DEVICE

• US 20190320896A1
• Filed: 04/23/2019
• Published: 10/24/2019
• Est. Priority Date: 04/23/2018
• Status: Active Grant

• Current Assignee: 3DT Holdings LLC
• Original Assignee: 3DT Holdings LLC
• Inventors: Kassab, Ghassan S., Dabiri, Aii
• Granted Patent: US 11,633,100 B2
• Time in Patent Office: Days
• CPC Class Codes: A61B 3/10 Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
• CPC Class Codes: A61B 3/1241 specially adapted for observation of ocular blood flow, e.g. by fluorescein angiography
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/0082 adapted for particular medical purposes
• CPC Class Codes: A61B 5/4064 Evaluating the brain A61B5/031, A61B5/369, A61B5/14553 take precedence
• CPC Class Codes: A61B 5/4088 Diagnosing of monitoring cognitive diseases, e.g. Alzheimer, prion diseases or dementia
• CPC Class Codes: A61K 49/0021 the fluorescent group being a small organic molecule
• CPC Class Codes: A61K 49/0043 Fluorescein, used in vivo

Abstract

A method of detecting injury to the brain such as stroke, concussion and cognitive dysfunction using a contrast agent and light source. The blood ocular barrier is disrupted when said injury occurs, allowing the entry of contrast agent into the aqueous and vitreous humor. An exemplary method comprises injecting a contrast agent into a peripheral location and then testing for leakage of contrast agent into the eye cavity by observing for light reflection, when a beam of light incidents on the contrast agent

Claims

1. A method of detecting stroke/concussion/cognitive dysfunction through the detection of contrast agent in the eye comprising the steps of:

injecting a contrast agent into a peripheral vessel;

incidenting or exciting a light into the eye wherein the light emits or reflect from the contrast agent; and

detecting the light returning from the eye.

2. The method of detecting contrast agent in the eye of claim 1, wherein the contrast agent is injected at a location other than the eye.

3. The method of detecting contrast agent in the eye of claim 1, wherein the contrast agent comprises gadolinium or sodium fluorescein or other contrast agent.

4. The method of detecting contrast agent in the eye of claim 1, further comprising the step of waiting a period of time after contrast agent injection.

5. The method of detecting contrast agent in the eye of claim 1, wherein the steps of incidenting light into the eye and detecting the returning light using a UV emission for gadolinium and fluorescence signal for sodium fluorescein, via a detection device.