SELECTIVE FAT REMOVAL USING PHOTOTHERMAL HEATING

• US 20190321099A1
• Filed: 01/24/2019
• Published: 10/24/2019
• Est. Priority Date: 05/08/2012
• Status: Active Grant

• Current Assignee: eLux Medical, Inc, Regents of the University of California (University of California)
• Original Assignee: eLux Medical, Inc, Regents of the University of California (University of California)
• Inventors: ALMUTAIRI, Adah, ALMUTAIRI, Khalid
• Granted Patent: US 11,628,010 B2
• Time in Patent Office: Days
• CPC Class Codes: A61B 18/04 by heating by applying electromagnetic radiation A61B18/18; hyperthermia using electric or magnetic fields, radiation or ultrasound A61N
• CPC Class Codes: A61B 18/203 applying laser energy to the outside of the body
• CPC Class Codes: A61B 2018/00452 Skin
• CPC Class Codes: A61B 2018/00458 Deeper parts of the skin, e.g. treatment of vascular disorders or port wine stains
• CPC Class Codes: A61B 2018/00464 Subcutaneous fat, e.g. liposuction, lipolysis
• CPC Class Codes: A61B 2018/00577 Ablation
• CPC Class Codes: A61B 2018/00809 measured thermochromatically
• CPC Class Codes: A61K 2800/81 Preparation or application process involves irradiation
• CPC Class Codes: A61K 2800/91 Injection
• CPC Class Codes: A61K 33/242 Gold; Compounds thereof
• CPC Class Codes: A61K 41/0052 Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
• CPC Class Codes: A61K 8/0241 Containing particulates characterized by their shape and/or structure see also A61K8/04, A61K8/11, and A61K8/14, further aspects are classified in A61K2800/40 and subcodes
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 9/14 Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles microspheres A61K9/16; microcapsules A61K9/50; nanocapsules, nanoparticles of the matrix type A61K9/51
• CPC Class Codes: A61M 1/892 with treatment of the collected fat
• CPC Class Codes: A61M 2202/08 Lipoids
• CPC Class Codes: A61M 2205/052 infrared
• CPC Class Codes: A61N 2005/0659 infrared
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent
• CPC Class Codes: A61N 5/067 using laser light
• CPC Class Codes: A61Q 19/06 : for countering cellulitis

Abstract

A system and method are provided for minimally-invasive selective fat removal from a target area by injecting the area with a solution of photo-absorbing nanoparticles and irradiating the injected area with a beam of near infrared (NIR) light. The NIR emission wavelength excites the nanoparticles to melt fat within the target area so that the liquefied fat can be aspirated from the target area. The nanoparticles may be gold nanorods having aspect ratios selected to produce surface plasmon resonance when irradiated with NIR light around 800 nm.

Claims

1. A system for selective removal of fat in a subject in need thereof, comprising:

a solution comprising gold nanorods suspended in a biocompatible liquid at a concentration range of 10¹¹ to 10¹³ GNR/mL;

an injector configured for distributing the solution within a target area comprising adipose tissue located beneath a skin surface;

a light source configured for delivering a series of pulses of near infrared light across the skin surface and into the target area for an exposure duration to induce surface plasmon resonance in the nanoparticles, wherein the near infrared light has a combination of optical parameters selected from the group consisting of beam energy, pulse duration, emission wavelength within a range of 700 to 900 nm, emission intensity, beam focus and beam area, the optical parameters and the exposure duration selected to excite the nanoparticles to liquefy fat within the target area.

2. The system of claim 1, wherein the light source is further configured for scanning across the target area in a plurality of passes.

3. The system of claim 1, further comprising a cooling material configured for application to the area of skin overlying the target area.

4. The system of claim 1, wherein the emission wavelength is 800 nm+10 nm.

5. The system of claim 1, wherein the gold nanorods have an aspect ratio in the range of 1:

3˜

1;

5.

6. The system of claim 1, wherein the gold nanorods having an axial diameter of approximately 10 nm and a longitudinal diameter in the range of 9 to 50 nm.

7. The system of claim 1, wherein the solution further comprises an anesthetic tumescent solution.

8. The system of claim 1, wherein the gold nanorods are functionalized with poly(ethylene-glycol).

9. The system of claim 1, wherein the beam area is within a range of 9 mm×

9 mm to 35 mm×

35 mm.

10. The system of claim 9, wherein the beam area is 2.3 cm×

3.5 cm.

11. The system of claim 1, wherein the beam energy is in a range of 1000 to 2000 J.

12. The system of claim 1, wherein the pulse duration is within a range of 30 ms to 60 ms.

13. A system for selective fat removal in a subject in need thereof, comprising:

a suspension of photo-absorbing gold nanoparticles having an aspect ratio in a range of 1;

3 to 1;

5 in a biocompatible solution;

an injector configured for subcutaneously injecting the suspension into a target area of adipose tissue of the subject; and

a near infrared light source configured for delivering a series of light pulses to the target area, the near infrared light source comprising a system controller for generating control signals controlling delivery parameters of the light beam, wherein the control signals comprise selection of an emission wavelength within an emission wavelength range of 700 to 900 nm, an emission intensity and an exposure duration, and wherein the system controller is configured to select the emission wavelength to excite the nanoparticles to generate heat to melt and liquefy fat within the target area and the emission intensity and exposure duration to modulate heating of tissue adjacent the fat.

14. The system of claim 13, wherein the near infrared light source is further configured for scanning across the target area in a plurality of passes.

15. The system of claim 13, further comprising a cooling material configured for application to an area of skin overlying the target area.

16. The system of claim 13, wherein the emission wavelength is 800 nm+10 nm.

17. The system of claim 13, wherein the gold nanoparticles are gold nanorods having an axial diameter of approximately 10 nm and a longitudinal diameter in the range of 9 to 50 nm.

18. The system of claim 13, wherein the biocompatible solution further comprises an anesthetic tumescent solution.

19. The system of claim 13, wherein the beam area is within a range of 9 mm×

9 mm to 35 mm×

35 mm.

20. The system of claim 13, wherein the beam energy is in a range of 1000 to 2000 J.

21. The system of claim 13, wherein the pulse duration is within a range of 30 ms to 60 ms.