LURASIDONE SOLID DISPERSION AND PREPARATION METHOD THEREOF
First Claim
1. A lurasidone solid dispersion comprising lurasidone, a medicinal hot melt carrier and an acidic regulator, wherein the lurasidone is in a form of free base.
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Accused Products
Abstract
It relates to a lurasidone solid dispersion and a preparation method, wherein the method comprises melting treatment of a mixture containing lurasidone, a medicinal hot melt carrier, optionally an acidic regulator and plasticizer in order to obtain the solid dispersion described herein, and wherein the lurasidone is provided in a form of free base. The lurasidone solid dispersion obtained by the preparation method according to the example of the invention has the characteristics of high dissolution rate (dissolution rate can reach 30%-70%) in a partial neutral medium (e.g. pH6.0). The bioavailability of lurasidone solid dispersion increased significantly and the food effect of lurasidone solid dispersion prepared from the example decreased remarkably. It overcomes the limitation of too many medication in the prior art and avoids the reduction of curative effect of the improper medication for the patient or even invalid, ensures the normal efficacy, thereby increases the patient'"'"'s medication flexibility and compliance.
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Citations
23 Claims
- 1. A lurasidone solid dispersion comprising lurasidone, a medicinal hot melt carrier and an acidic regulator, wherein the lurasidone is in a form of free base.
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4. A method of preparing lurasidone solid dispersion comprising:
- melting and mixing a mixture containing lurasidone and a medicinal hot melt carrier; and
cooling the mixture to give the lurasidone solid dispersion, wherein the lurasidone is in a form of free base. - View Dependent Claims (6, 7, 9, 10, 11, 12, 17, 21, 22)
- melting and mixing a mixture containing lurasidone and a medicinal hot melt carrier; and
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5. A method of preparing lurasidone solid dispersion comprising:
- melting and mixing a mixture containing lurasidone, a medicinal hot melt carrier, an acidic regulator, and optionally a plasticizer; and
cooling the mixture to give the lurasidone solid dispersion, wherein the lurasidone is in a form of free base. - View Dependent Claims (8, 18, 19, 20)
- melting and mixing a mixture containing lurasidone, a medicinal hot melt carrier, an acidic regulator, and optionally a plasticizer; and
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15-16. -16. (canceled)
Specification