METHOD FOR PREVENTING OR TREATING TUBERCULOSIS BY A P53 EXPRESSION REGULATING COMPOSITION FOR M. TUBERCULOSIS CONTROL IN CELLS AND THE USE THEREOF

• US 20190321368A1
• Filed: 04/23/2019
• Published: 10/24/2019
• Est. Priority Date: 04/23/2018
• Status: Active Grant

• Current Assignee: The Industry & Academic Cooperation In Chungnam National University
• Original Assignee: The Industry & Academic Cooperation In Chungnam National University
• Inventors: SONG, Chang-Hwa
• Granted Patent: US 10,806,736 B2
• Time in Patent Office: Days
• CPC Class Codes: A61K 31/519 ortho- or peri-condensed with heterocyclic rings
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61P 31/06 for tuberculosis

Abstract

The present invention relates to a pharmaceutical composition for preventing or treating tuberculosis comprising compound (K279-1558) as an active ingredient. Compound (K279-1558) which is an active ingredient of the present invention has an effect of inhibiting the proliferation of M. tuberculosis by inducing apoptosis of macrophages infected with tuberculosis through the overexpression of p53. Therefore, the method of the present invention comprising said compound as an active ingredient could be usefully used for preventing or treating tuberculosis.

Claims

1. A method for preventing or treating tuberculosis by administering into an individual a pharmaceutical composition comprising the compound of the following formula 1 as an active ingredient:

2. The method of claim 1, wherein the compound of formula 1 overexpresses p53.

3. The method of claim 2, wherein the p53 overexpression inhibits the proliferation of M. tuberculosis by inducing apoptosis of macrophages infected with M. tuberculosis.

4. The method of claim 1, wherein an anti-tuberculosis drug is used together with the compound of formula 1.

5. The method of claim 4, wherein the anti-tuberculosis drug is rifampicin, isoniazid, ethambutol or pyrazinamide.

6. The method of any one of claim 1, wherein the tuberculosis is eye tuberculosis, skin tuberculosis, adrenal tuberculosis, renal tuberculosis, epididymal tuberculosis, lymphatic gland tuberculosis, laryngeal tuberculosis, middle ear tuberculosis, intestinal tuberculosis, multidrug-resistant tuberculosis, pulmonary tuberculosis, sputum tuberculosis, bone tuberculosis, throat tuberculosis, lymphatic tuberculosis, lung deficiency, breast tuberculosis, or spinal tuberculosis.