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ANTIBODY DRUG CONJUGATES FOR ABLATING HEMATOPOIETIC STEM CELLS

  • US 20190321483A1
  • Filed: 12/19/2017
  • Published: 10/24/2019
  • Est. Priority Date: 12/21/2016
  • Status: Active Grant
First Claim
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1. A conjugate of Formula (I) or a pharmaceutically acceptable salt thereof;


  • A-(LB-(D)n)y



    Formula (I)wherein;

    A is an antibody fragment that specifically binds to human cKIT;

    LB is a linker;

    D is a cytotoxic agent;

    n is an integer from 1 to 10, andy is an integer from 1 to 10.

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