IN SITU SOLIDIFYING HOMOGENEOUS SOLUTIONS AND METHODS OF MAKING AND USING THEREOF
First Claim
1. A method for reducing or inhibiting blood flow in a blood vessel of a subject comprising introducing into the vessel a homogeneous solution comprising water, at least one polycation, at least one polyanion, and monovalent ions in water, wherein the concentration of the monovalent ions in the homogeneous solution is greater than the concentration of the monovalent ions in the blood vessel of the subject, whereupon introduction of the homogeneous solution into the vessel the homogeneous solution is converted to a solid in situ within the vessel.
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Accused Products
Abstract
Described herein are fluid complex coacervates that produce solid adhesives in situ. Oppositely charged polyelectrolytes were designed to form fluid adhesive complex coacervates at ionic strengths higher than the ionic strength of the application site, but an insoluble adhesive solid or gel at the application site. When the fluid, high ionic strength adhesive complex coacervates are introduced into the lower ionic strength application site, the fluid complex coacervate is converted to a an adhesive solid or gel as the salt concentration in the complex coacervate equilibrates to the application site salt concentration. In one embodiment, the fluid complex coacervates are designed to solidify in situ at physiological ionic strength and have numerous medical applications. In other aspects, the fluid complex coacervates can be used in aqueous environment for non-medical applications.
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Citations
28 Claims
- 1. A method for reducing or inhibiting blood flow in a blood vessel of a subject comprising introducing into the vessel a homogeneous solution comprising water, at least one polycation, at least one polyanion, and monovalent ions in water, wherein the concentration of the monovalent ions in the homogeneous solution is greater than the concentration of the monovalent ions in the blood vessel of the subject, whereupon introduction of the homogeneous solution into the vessel the homogeneous solution is converted to a solid in situ within the vessel.
Specification