SYSTEM AND METHOD FOR INDUCING SLEEP BY TRANSPLANTING MENTAL STATES

• US 20190321583A1
• Filed: 04/18/2019
• Published: 10/24/2019
• Est. Priority Date: 04/20/2018
• Status: Active Grant

• Current Assignee: Neuroenhancement Lab, LLC
• Original Assignee: Neuroenhancement Lab, LLC
• Inventors: Poltorak, Alexander
• Granted Patent: US 11,364,361 B2
• Time in Patent Office: Days
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/245 specially adapted for magnetoencephalographic [MEG] signals
• CPC Class Codes: A61B 5/291 for electroencephalography [EEG]
• CPC Class Codes: A61B 5/316 Modalities, i.e. specific diagnostic methods
• CPC Class Codes: A61B 5/369 Electroencephalography [EEG] devices for psychotechnics A61B5/16
• CPC Class Codes: A61B 5/378 Visual stimuli
• CPC Class Codes: A61B 5/38 Acoustic or auditory stimuli
• CPC Class Codes: A61B 5/389 Electromyography [EMG]
• CPC Class Codes: A61B 5/4812 Detecting sleep stages or cycles
• CPC Class Codes: A61B 5/486 Bio-feedback A61B5/375 takes precedence
• CPC Class Codes: A61B 5/7253 characterised by using transforms
• CPC Class Codes: A61M 2021/0016 by the smell sense
• CPC Class Codes: A61M 2021/0022 by the tactile sense, e.g. vibrations
• CPC Class Codes: A61M 2021/0027 by the hearing sense
• CPC Class Codes: A61M 2021/0044 by the sight sense
• CPC Class Codes: A61M 2021/0055 with electric or electro-magnetic fields
• CPC Class Codes: A61M 2021/0072 with application of electrical currents
• CPC Class Codes: A61M 21/02 for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia for massage A61H; electrotherapy A61N, e.g. applying alternating or intermittent electric currents for producing anaesthesia A61N1/36021
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2230/08 Other bio-electrical signals
• CPC Class Codes: A61M 2230/10 : Electroencephalographic signals
• CPC Class Codes: A61N 1/0456 : Specially adapted for transcutaneous electrical nerve stimulation [TENS]
• CPC Class Codes: A61N 1/36025 : for treating a mental or cerebral condition
• CPC Class Codes: A61N 1/36031 : using physiological parameters for adjustment
• CPC Class Codes: A61N 2/006 : for magnetic stimulation of nerve tissue

Abstract

A method of replicating a mental state of a first subject in a second subject comprising: capturing a mental state of the first subject represented by brain activity patterns; and replicating the mental state of the first subject in the second subject by inducing the brain activity patterns in the second subject.

Claims

1. A method of inducing a sleep cycle in a subject, comprising modulating a waveform on at least one of a visual stimulus and an auditory stimulus for use in visual or auditory stimulation of the subject, to induce the sleep cycle in the subject, wherein the waveform is generated by recording neural correlates of at least one sleep cycle of a donor, processing the recorded neural correlates of the at least one sleep cycle to decode at least one of a temporal and a spatial pattern;

and transforming the at least one of the temporal and the spatial pattern into the modulated waveform.

2. The method of claim 1, wherein the recording of neural correlates of at least one sleep stage of a donor is done by recording at least one of an electroencephalogram (EEG), a magnetoencephalogram (MMG), and a functional magnetic resonance (fMRI).

3. The method of claim 1, further comprising processing the recorded neural correlates of at the sleep stage using a statistical analysis technique.

4. The method of claim 3, wherein the statistical analysis technique is one of a Principal Component Analysis (PCA), a Spatial Principal Component Analysis (Spatial PCA), a Kernel Principal Component Analysis (Kernel PCA), a Nonlinear Principal Component Analysis (NLPCA), an Independent Component Analysis (ICA), Singular Value Decomposition (SVD), Factor Analysis, a Gaussian Process Latent Variable Model (GPLVM), a Curvilinear Component Analysis (CCA), a Diffeomorphic Dimensionality Reduction (Diffeomap), a Gelfand transform, a Fourier transform, a Fourier-Pontryagin transform, a Laplace transform, a short-time Fourier transform (STFT), a fractional Fourier transform (FRFT), Laplacian Eigenmaps, a spectral analysis, a wavelet analysis, an eigenvector-based multivariable analysis, a factor analysis, canonical correlation analysis (CCA), and a nonlinear dimensionality reduction (NLDR).

5. The method of claim 1, wherein the transforming of the at least one of the temporal and a spatial pattern into the waveform comprises performing an inversion transform on the at least one of the temporal and the spatial pattern of the donor into the waveform, adapted to expose the at least one of the temporal and the spatial pattern to the subject.

6. The method of claim 1, wherein the subject and the donor are a single human at different times.

7. The method of claim 1, wherein the at least one of the light stimulus and the sound stimulus is frequency modulated corresponding to the waveform.

8. The method of claim 1, wherein the at least one of the light stimulus and the sound stimulus comprises the sound stimulus, modulated to provide at least one of a binaural stimulation and an isochronic tones stimulation.

9. The method of claim 1, wherein the at least one of the light stimulus and the sound stimulus comprises the sound stimulus, which is at least one of an audible sound frequency, an ultrasonic sound frequency, and an infrasonic sound frequency.

10. The method of claim 1, wherein the at least one of the light stimulus and the sound stimulus comprises the sound stimulus, comprising at least one of a random noise, music, a sound of rainfall, a sound of ocean waves, and a sound of a human voice.

11. The method of claim 1, wherein the at least one of the light stimulus and the sound stimulus comprises the light stimulus, which is at least one of amplitude modulated and pulse modulated.

12. The method of claim 1, further comprising pulse rate modulating the waveform on at least one of a light stimulus and a sound stimulus corresponding to the waveform.

13. The method of claim 1, further comprising amplitude modulating the waveform on at least one of a light stimulus and a sound stimulus corresponding to the waveform.

14. The method of claim 1, wherein the sleep cycle comprises a plurality of sleep stages, comprising a REM sleep stage.

15. The method of claim 1, wherein the sleep cycle comprises a plurality of sleep stages, comprising a non-REM sleep stage.

16. The method of claim 1, wherein the sleep cycle comprises a natural sequence of sleep stages comprising at least one full sleep cycle.

17. The method of claim 1, wherein the recording of neural correlates of at least one sleep cycle comprises recording of neural correlates of at least two full sleep cycles.

18. The method of claim 1, further comprising monitoring the sleep stage of the subject, distinct from recording the neural correlates, and adapting the waveform selectively dependent on the monitored sleep stage.

19. The method of claim 1, further comprising stimulating the subject with at least one of a visual stimulus and an auditory stimulus modulated according to a first portion of the waveform, correlating the stimulation of the subject with a respective sleep stage of the subject during stimulation, and selecting a second portion of the waveform representative of the at least one sleep stage of the donor that corresponds to the respective sleep stage of the subject.

20. The method of claim 19, further comprising stimulating the subject with the at least one of the visual stimulus and the auditory stimulus, and modifying the stimulation after determining that the subject is not in the sleep stage sought to be induced corresponding to the at least one sleep stage of the donor.

21. The method of claim 1, further comprising adjusting an ambient temperature surrounding the subject for a specific sleep stage corresponding to the at least one sleep stage of the donor.

22. The method of claim 1, further comprising superimposing on said at least one of the light stimulus and the sound stimulus a signal having a rhythm having a fixed frequency of less than approximately 100 Hz.

23. The method of claim 1, wherein the fixed frequency is approximately 40 Hz.

24. A method of inducing sleep in a mammal, comprising:

retrieving a stored modulation sequence for at least one of an audio signal and a visual signal derived from captured neural correlates of at least one sleep cycle, which is adapted, when used to stimulate the mammal, to induce at least one sleep cycle in the mammal; and

presenting the at least one of the audio signal and the visual signal having the modulation sequence to the mammal, to induce the mammal to enter a respective sleep cycle.

25. A system for inducing sleep in a subject, comprising:

a memory configured to store a waveform, derived from neural correlates of at least one sleep stage, processed to derive at least one of a temporal and a spatial pattern transformed into the waveform for modulating at least one of a visual stimulus and an auditory stimulus; and

at least one of a visual stimulator and an auditory stimulator, configured to retrieve the waveform and modulate the waveform on at least one of a visual stimulus and an auditory stimulus, for use in stimulating a subject to induce a sleep.

26. A computer readable medium, storing non-transitory instructions for controlling a programmable processor for presenting at least one of a visual stimulus and an auditory stimulus to a subject to induce sleep, comprising:

instructions to define a waveform pattern derived from neural correlates of at least one sleep stage, processed to derive at least one of a temporal and a spatial pattern transformed into the waveform;

instructions to modulate the waveform on at least one of a visual stimulus and an auditory stimulus for presentation to the subject; and

instructions for controlling the modulation of the waveform according to a sleep cycle.