METHOD AND APPARATUS FOR PREVENTING OR TERMINATING EPILEPTIC SEIZURES
First Claim
1. A method of preventing or terminating seizures, comprising:
- determining neuronal synchrony between at least two sites of a brain of a patient;
stimulating the brain with at least two implanted electrodes, each implanted in a different one of at least two regions of the brain, with a predetermined seizure termination frequency determined from frequencies measured across a seizure occurrence in the at least two regions of the brain.
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Accused Products
Abstract
A method and apparatus for preventing or terminating seizures, by stimulating a brain with at least two implanted electrodes, each implanted in a different one of at least two regions of the brain, with a frequency to emulate neuronal synchrony. Upon detecting a potential or actual seizure occurrence, the frequency is electrically applied to the brain upon the detection to preempt or terminate the potential or actual seizure occurrence. Parts in the brain, where brain electrical activity is being measured, that have the highest connectivity are determined by phase-locking coherence. The select subset of areas showing synchrony, i.e., only those with the highest coherence that will best permit inducing a large global synchrony, are stimulated to preempt or terminate the potential or actual seizure occurrence.
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Citations
20 Claims
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1. A method of preventing or terminating seizures, comprising:
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determining neuronal synchrony between at least two sites of a brain of a patient; stimulating the brain with at least two implanted electrodes, each implanted in a different one of at least two regions of the brain, with a predetermined seizure termination frequency determined from frequencies measured across a seizure occurrence in the at least two regions of the brain. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method of preventing or terminating seizures, comprising:
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monitoring for and/or determining neuronal synchrony between a plurality of sites of a brain of a patient; comparing measurements from and between at least pairs of the plurality of sites to determine at least a pair of sites with a higher electrical coherence than one or more others of the at least pairs; determining a frequency at the higher electrical coherence; and stimulating the brain at the frequency. - View Dependent Claims (11, 12, 13, 14, 15)
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16. An apparatus for preventing or terminating seizures, comprising:
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a neurostimulator including a stimulation generator and a power supply connected to the stimulation generator, wherein the stimulation generator generates electrical stimulation for and through at least two electrodes implantable within a brain; and a control protocol on a non-transitory recordable medium in executable combination with the stimulation generator and adapted to stimulate at least two regions of the brain with a frequency to emulate neuronal synchrony, wherein the frequency comprises a predetermined seizure termination frequency predetermined from seizure frequencies measured across a seizure occurrence in the at least two regions of the brain. - View Dependent Claims (17, 18, 19, 20)
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Specification