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METHODS OF MANUFACTURING INJECTABLE MICROGEL SCAFFOLDS

  • US 20190321797A1
  • Filed: 06/28/2019
  • Published: 10/24/2019
  • Est. Priority Date: 12/29/2016
  • Status: Active Grant
First Claim
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1. A method comprising:

  • a) providing a membrane filtration system comprising a solid support with pores, each pore having a diameter of at most 9 micrometers (μ

    m);

    b) transferring microgel particles, each microgel particle having a diameter of between or about 10 μ

    m and 500 μ

    m from a first solvent to a second solvent by controlled addition of a third solvent to the first solvent, wherein the second solvent is immiscible with the first solvent;

    c) maintaining a single miscible phase containing the microgel particles;

    d) applying the single miscible phase containing the microgel particles to a membrane of the membrane filtration system; and

    e) removing an impurity from the flowable microgel particles using size exclusion filtration by the membrane filtration system, thereby producing purified microgel particles.

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