METHODS OF MANUFACTURING INJECTABLE MICROGEL SCAFFOLDS
First Claim
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1. A method comprising:
- a) providing a membrane filtration system comprising a solid support with pores, each pore having a diameter of at most 9 micrometers (μ
m);
b) transferring microgel particles, each microgel particle having a diameter of between or about 10 μ
m and 500 μ
m from a first solvent to a second solvent by controlled addition of a third solvent to the first solvent, wherein the second solvent is immiscible with the first solvent;
c) maintaining a single miscible phase containing the microgel particles;
d) applying the single miscible phase containing the microgel particles to a membrane of the membrane filtration system; and
e) removing an impurity from the flowable microgel particles using size exclusion filtration by the membrane filtration system, thereby producing purified microgel particles.
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Abstract
Disclosed herein are methods of manufacturing injectable microgel scaffolds, including methods of producing, purifying and concentrating microgel particles therein. The microgel scaffolds of the present disclosure are useful for a wide range of applications, such as stabilizing an implanted medical device in an implant site in a subject. The microgel scaffolds are fluidic during application and annealed or crosslinked after application to the implant site in the subject. The microgel scaffolds may contain various therapeutic agents, including antibiotics and analgesics, throughout the gel.
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Citations
20 Claims
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1. A method comprising:
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a) providing a membrane filtration system comprising a solid support with pores, each pore having a diameter of at most 9 micrometers (μ
m);b) transferring microgel particles, each microgel particle having a diameter of between or about 10 μ
m and 500 μ
m from a first solvent to a second solvent by controlled addition of a third solvent to the first solvent, wherein the second solvent is immiscible with the first solvent;c) maintaining a single miscible phase containing the microgel particles; d) applying the single miscible phase containing the microgel particles to a membrane of the membrane filtration system; and e) removing an impurity from the flowable microgel particles using size exclusion filtration by the membrane filtration system, thereby producing purified microgel particles. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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- 9. The method of 1, wherein the purified microgel particles comprise a backbone polymer and annealing components.
Specification