SINGLE-CHANNEL, HYBRID BIOSENSOR AND SENSOR SYSTEM INCLUDING THE SAME
First Claim
1. A single-channel, chemical-immunological hybrid biosensor comprising a reaction strip in the form of a porous membrane through which a sample moves by capillary action wherein the reaction strip comprises:
- a sample transfer pad having a predetermined length and along which the sample is transferred from one end to the other in the lengthwise direction;
one or more immuno-reaction zones comprising capture recognition elements specifically binding to binding reaction markers in the sample to generate first reaction signals on the sample transfer pad; and
at least one chemical reaction zone comprising a matrix to supply substrate(s) chemically reacting with a chemical reaction marker in the sample to generate a second reaction signal, where the sample is received in a manner that is spatially separated from the sample transfer pad and, thus, the chemical reaction occurs independently from the binding reactions.
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Abstract
A single-channel, chemical-immunological hybrid biosensor is disclosed. According to an embodiment, the hybrid biosensor includes a reaction strip 100 in the form of a porous membrane through which a sample 1 moves by capillary action. the reaction strip 100 is in the form of a porous membrane through which the sample 1 moves by capillary action. Biomarkers in the sample 1 are independently detected based on a chemical reaction and binding reactions on the reaction strip 100.
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Citations
23 Claims
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1. A single-channel, chemical-immunological hybrid biosensor comprising a reaction strip in the form of a porous membrane through which a sample moves by capillary action wherein the reaction strip comprises:
- a sample transfer pad having a predetermined length and along which the sample is transferred from one end to the other in the lengthwise direction;
one or more immuno-reaction zones comprising capture recognition elements specifically binding to binding reaction markers in the sample to generate first reaction signals on the sample transfer pad; and
at least one chemical reaction zone comprising a matrix to supply substrate(s) chemically reacting with a chemical reaction marker in the sample to generate a second reaction signal, where the sample is received in a manner that is spatially separated from the sample transfer pad and, thus, the chemical reaction occurs independently from the binding reactions. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
- a sample transfer pad having a predetermined length and along which the sample is transferred from one end to the other in the lengthwise direction;
Specification