MAGNETIC BIOSENSOR DESIGN FOR MANUFACTURING

• US 20190321824A1
• Filed: 07/02/2019
• Published: 10/24/2019
• Est. Priority Date: 01/06/2017
• Status: Abandoned Application

• Current Assignee: In Diagnostics, Inc.
• Original Assignee: In Diagnostics, Inc.
• Inventors: IZYUMIN, Igor, FLORESCU, Octavian
• Application Number:
  US16/460,480
• Publication Number:
  US 20190321824A1
• Time in Patent Office: Days
• CPC Class Codes: B01L 2200/0668 Trapping microscopic beads
• CPC Class Codes: B01L 2200/143 Quality control, feedback systems
• CPC Class Codes: B01L 2300/0636 Integrated biosensor, microarrays
• CPC Class Codes: B01L 2300/0681 Filter
• CPC Class Codes: B01L 2400/0406 capillary forces
• CPC Class Codes: B01L 2400/043 magnetic forces
• CPC Class Codes: B01L 3/5027 by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip B01L3/5023 takes precedence; micromixers B01F33/30; microreactors for synthesis B01J19/0093; microcapillary devices in general B81B1/00
• CPC Class Codes: B01L 3/502707 characterised by the manufacture of the container or its components by shaping or joining plastic parts B29C59/00, B29C65/00; by laminating B32B37/00; manufacture of microstructural devices in general B81C
• CPC Class Codes: B01L 3/502715 characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
• CPC Class Codes: B01L 3/502761 specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules investigating characteristics of particles G01N15/00
• CPC Class Codes: G01N 21/77 by observing the effect on a chemical indicator
• CPC Class Codes: G01N 27/745 for detecting magnetic beads used in biochemical assays concerning the assays G01N33/54326; sensors therefor G01R33/1269; automatic analysers therefor G01N35/0098
• CPC Class Codes: G01N 33/48707 by electrical means G01N33/49, G01N33/493 take precedence
• CPC Class Codes: G01N 33/49 Blood chemical methods for determining blood cell populations G01N33/5094; chemical analysis of blood groups or blood types G01N33/80
• CPC Class Codes: G01N 33/493 urine
• CPC Class Codes: G01N 33/5302 Apparatus specially adapted for immunological test procedures
• CPC Class Codes: G01N 33/54333 Modification of conditions of immunological binding reaction, e.g. use of more than one type of particle, use of chemical agents to improve binding, choice of incubation time or application of magnetic field during binding reaction
• CPC Class Codes: H05K 1/0272 Adaptations for fluid transport, e.g. channels, holes
• CPC Class Codes: H05K 1/182 associated with components mounted in the printed circuit board, e.g. insert mounted components [IMC]
• CPC Class Codes: H05K 1/185 Components encapsulated in the insulating substrate of the printed circuit or incorporated in internal layers of a multilayer circuit semiconductor chips encapsulated by interconnect and support structures H01L23/5389, H01L24/00
• CPC Class Codes: H05K 2201/10121 : Optical component, e.g. opto-electronic component
• CPC Class Codes: H05K 2201/10151 : Sensor

Abstract

A stand-alone assay system for POC IVD that is fast, easy to use, inexpensive and delivers laboratory quality results for one or more target analytes from a small volume of unprocessed aqueous sample is disclosed. The stand-alone assay system is a disposable digital device. The stand-alone assay system integrates a sampling system that relies on users swiping a lanced finger containing an unprocessed aqueous sample such as whole blood across a sample inlet to transfer or deposit the unprocessed aqueous sample on to a membrane filter or into a capillary. The system can have a planarized testing surface on which retained magnetic particles are sensed.

Claims

1. An assay system comprising:

a printed circuit board;

an integrated circuit mounted on the printed circuit board, wherein the integrated circuit comprises a functionalized surface for specifically binding to magnetic particles, and wherein the integrated circuit comprises sensors for detecting the magnetic particles specifically bound to the functionalized surface;

an energy source configured to emit energy onto the functionalized surface, and wherein the sensors are configured to detect the energy;

wherein at least a part of the functionalized surface of the integrated surface is coplanar with a surface of the printed circuit board.

2. The system of claim 1, wherein an edge of the functionalized surface of the integrated circuit forms a seal with an edge of the surface of the printed circuit board.

3. The system of claim 1, further comprising a first separation conductor configured to produce one or more magnetic separation force to remove non-specifically bound magnetic particles from the sensors.

4. The system of claim 1, further comprising a second separation conductor configured to produce one or more magnetic separation force to remove non-specifically bound magnetic particles from the sensors.

5. The system of claim 1, wherein the printed circuit board comprises a fluidic bridge.

6. The system of claim 1, wherein the sensors comprise optical sensors.

7. The system of claim 1, wherein the energy source comprises a light source.

8. An assay system comprising:

a printed circuit board;

an integrated circuit comprising a functionalized surface for specifically binding to magnetic particles, and wherein the integrated circuit comprises sensors for detecting the magnetic particles specifically bound to the functionalized surface;

an energy source configured to emit energy onto the functionalized surface, and wherein the sensors are configured to detect the energy; and

a planarization surface on the functionalized surface and the surface of the printed circuit board.