HDAC8 INHIBITORS FOR TREATING CANCER
4 Assignments
0 Petitions
Accused Products
Abstract
Provided herein, inter alia, are compound and methods of treating cancer by inhibiting HDAC8.
-
Citations
43 Claims
-
1-20. -20. (canceled)
- 21. A method of treating cancer in a subject in need thereof, said method comprising administering an effective amount of an HDAC8 inhibitor to said subject.
-
28. (canceled)
- 31. A method of inhibiting HDAC8 mediated deacetylation of p53, said method comprising contacting HDAC8 with a HDAC8 inhibitor in the presence of p53, thereby inhibiting HDAC8 deacetylation of p53.
-
36. A method of activating p53 in vivo, said method comprising:
-
(i) contacting a cell with a HDAC8 inhibitor in the presence of HDAC8, wherein the cell is an AML cell; and (ii) allowing said HDAC8 inhibitor to contact said HDAC8, thereby inhibiting said HDAC8 and activating p53. - View Dependent Claims (37, 38, 39)
-
-
43. A method of treating cancer in a subject in need thereof, said method comprising administering an effective amount of an HDAC8 inhibitor compound selected from the group consisting of:
Specification