AGONISTIC ANTIBODIES THAT BIND HUMAN CD40 AND USES THEREOF
First Claim
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1. An agonistic isolated monoclonal antibody that binds to human CD40, wherein the antibody directly activates antigen presenting cells (APCs) and/or increases an immune response to an antigen either:
- (a) independent of Fc receptor binding;
(b) without inducing antibody-dependent cellular cytotoxicity (ADCC) of CD40 expressing cells;
(c) without inducing complement dependent cellular cytotoxicity (CDC) of CD40 expressing cells; and
/or(d) independent of Fc receptor binding and is capable of synergizing with CD40L.
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Abstract
Isolated monoclonal agonistic antibodies which bind to human CD40 and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies.
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Citations
27 Claims
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1. An agonistic isolated monoclonal antibody that binds to human CD40, wherein the antibody directly activates antigen presenting cells (APCs) and/or increases an immune response to an antigen either:
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(a) independent of Fc receptor binding; (b) without inducing antibody-dependent cellular cytotoxicity (ADCC) of CD40 expressing cells; (c) without inducing complement dependent cellular cytotoxicity (CDC) of CD40 expressing cells; and
/or(d) independent of Fc receptor binding and is capable of synergizing with CD40L. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17, 18, 22, 23)
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2. An isolated antibody which binds to human CD40 and comprises heavy and light chain variable regions, wherein the heavy and light chain variable regions respectively comprise an amino acid sequence which is at least 80% identical to:
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(a) SEQ ID NOs;
3 and 4;(b) SEQ ID NOs;
17 and 18;(c) SEQ ID NOs;
31 and 32;(d) SEQ ID NOs;
45 and 46;(e) SEQ ID NOs;
59 and 60;(f) SEQ ID NO;
73 and 74;(g) SEQ ID NO;
87 and 88;
or(h) SEQ ID NO;
101 and 102.
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3. An isolated antibody which binds to human CD40 and comprises heavy and/or light chain variable regions having the amino acid sequence as set forth in:
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(a) SEQ ID NOs;
3 and/or 4;(b) SEQ ID NOs;
17 and/or 18;(c) SEQ ID NOs;
31 and/or 32;(d) SEQ ID NOs;
45 and/or 46;(e) SEQ ID NOs;
59 and/or 60;(f) SEQ ID NO;
73 and/or 74;(g) SEQ ID NO;
87 and/or 88;
or(h) SEQ ID NO;
101 and/or 102. - View Dependent Claims (5, 6, 8, 9)
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4. An isolated antibody which binds to human CD40 and comprises the CDR sequences from the heavy and light chain variable regions respectively having the amino acid sequences set forth in:
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(a) SEQ ID NOs;
3 and 4;(b) SEQ ID NOs;
17 and 18;(c) SEQ ID NOs;
31 and 32;(d) SEQ ID NOs;
45 and 46;(e) SEQ ID NOs;
59 and 60;(f) SEQ ID NO;
73 and 74;(g) SEQ ID NO;
87 and 88;
or(h) SEQ ID NO;
101 and 102. - View Dependent Claims (7, 19, 20, 21, 24, 25, 26, 27)
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Specification