Three dimensional printing with biomaterial

• US 20190322769A1
• Filed: 12/29/2017
• Published: 10/24/2019
• Est. Priority Date: 12/30/2016
• Status: Active Application

• Current Assignee: Teknologian tutkimuskeskus VTT Oy
• Original Assignee: Teknologian tutkimuskeskus VTT Oy
• Inventors: Lahtinen, Panu, Metsa-Kortelainen, Sini, Nurmela, Asta, Iitti, Hanna, Mahlberg, Riitta
• Application Number:
  US16/469,656
• Publication Number:
  US 20190322769A1
• Time in Patent Office: Days
• CPC Class Codes: B29C 64/165 using a combination of solid and fluid materials, e.g. a powder selectively bound by a liquid binder, catalyst, inhibitor or energy absorber
• CPC Class Codes: B29K 2001/00 Use of cellulose, modified cellulose or cellulose derivatives, e.g. viscose, as moulding material
• CPC Class Codes: B29K 2005/00 Use of polysaccharides or derivatives as moulding material
• CPC Class Codes: B33Y 10/00 Processes of additive manufacturing
• CPC Class Codes: B33Y 50/00 Data acquisition or data processing for additive manufacturing
• CPC Class Codes: B33Y 70/00 Materials specially adapted for additive manufacturing
• CPC Class Codes: B33Y 70/10 Composites of different types of material, e.g. mixtures of ceramics and polymers or mixtures of metals and biomaterials
• CPC Class Codes: B33Y 80/00 Products made by additive manufacturing
• CPC Class Codes: C08B 15/005 Crosslinking of cellulose derivatives
• CPC Class Codes: C08J 2305/04 Alginic acid; Derivatives thereof
• CPC Class Codes: C08J 2401/02 Cellulose; Modified cellulose
• CPC Class Codes: C08J 3/075 Macromolecular gels
• CPC Class Codes: C08J 3/246 Intercrosslinking of at least two polymers
• CPC Class Codes: C08K 2003/325 Calcium, strontium or barium phosphate
• CPC Class Codes: C08K 3/30 Sulfur-, selenium- or tellurium-containing compounds
• CPC Class Codes: C08K 3/32 Phosphorus-containing compounds
• CPC Class Codes: C08K 3/346 Clay
• CPC Class Codes: C08K 5/053 Polyhydroxylic alcohols
• CPC Class Codes: C08L 1/02 Cellulose; Modified cellulose
• CPC Class Codes: C08L 1/04 Oxycellulose; Hydrocellulose , e.g. microcrystalline cellulose
• CPC Class Codes: C08L 29/04 : Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
• CPC Class Codes: C08L 43/04 : Homopolymers or copolymers of monomers containing silicon
• CPC Class Codes: C08L 5/04 : Alginic acid; Derivatives thereof

Abstract

According to an example aspect of the present invention, there is provided a method for producing a three-dimensional fully bio-based object by forming successive layers of biomaterial under computer control. Depending on the features necessary for the end-use application, properties of the produced 3D-object can be tailored by selecting suitable material component shares.

Claims

1. A material for three-dimensional printing, wherein the material is 100% bio-based and comprises 10 to 20 weight-% of an alginate and 1 to 30 weight-% of nanocellulose of a dry matter of the material.

2. The material according to claim 1, further comprising 5 to 95 weight-% of sugar alcohol.

3. The material according to claim 1, further comprising 40 to 70 weight-% of glycerol, polyglycerol, or triacetin.

4. The material according to claim 1, further comprising a filler selected from the group consisting of talc, hydroxyapatite, and tri-calcium phosphate.

6. The material according to claim 1, wherein the material has antimicrobial properties.

7. A method for producing a three-dimensional object comprising forming successive layers of the material according to claim 1 under computer control.

8. The method according to claim 7, further comprising:

(a) optionally mixing an alginate with a sugar alcohol to form a fluid mixture,

(b) mixing the formed fluid mixture if formed or otherwise polyvinyl alcohol with nanocellulose to form a hydrogel,

(c) optionally carrying out ionic cross-linking of the hydrogel with a cross-linking agent,

(d) bio-printing a three-dimensional object from the hydrogel, and

(e) curing the bio-printed three-dimensional object at room temperature, in an oven at temperatures between 100°

C. and 150°

C., or by freeze-drying.

9. The method according to claim 7, wherein step (c) is not performed and is replaced by filler loading, after which the material comprises up to 90 weight-% dry matter of a filler, and wherein the filler is selected from the group consisting of talc, hydroxyapatite, and tri-calcium phosphate.

10. The method according to claim 7, wherein step(a) is performed, and wherein the alginate is mixed with glycerol to form the fluid mixture in step (a).

11. A three dimensionally printed object formed from the material of claim 1.

12. The three dimensionally printed object according to claim 11, further comprising 5 to 95 weight-% of a sugar alcohol.

5. (canceled)

13. A three dimensionally printed object, wherein the material is bio-based and comprises 10 to 49 weight-% of polyvinyl alcohol and 1 to 30 weight-% of nanocellulose of a dry matter of the object.

14. (canceled)

15. (canceled)