×

EPIGENETIC MARKERS AND RELATED METHODS AND MEANS FOR THE DETECTION AND MANAGEMENT OF OVARIAN CANCER

  • US 20190323090A1
  • Filed: 12/15/2017
  • Published: 10/24/2019
  • Est. Priority Date: 12/16/2016
  • Status: Abandoned Application
First Claim
Patent Images

1. A method of determining the presence or absence of, or response to therapy against, an ovarian cancer in a woman, said method comprising the steps:

  • providing a biological sample from said woman, said sample comprising cell-free DNA of said woman; and

    determining, in at least one molecule of said cell-free DNA, the methylation status at one or more CpGs located within one or more of the nucleotide sequences independently selected from the group consisting of;

    SEQ ID NOs;

    1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30 and 31, or a nucleotide sequence present within about 2,000 bp 5′

    or 3′

    thereof, or an allelic variant and/or complementary sequence of said nucleotide sequence(s),wherein, the presence in at least one of said cell-free DNA molecules of one or more;

    (i) methylated CpGs associated with one or more of said nucleotide sequences independently selected from;

    SEQ ID NOs;

    1, 2, 3, 4, 10, 12, 14, 15, 18, 19, 20, 21, 23, 24, 25, 26, 27, 28, 29 and 30; and

    /or (ii) un-methylated CpGs associated with one or more of said nucleotide sequences independently selected from;

    SEQ ID NOs;

    5, 6, 7, 8, 9, 11, 13, 16, 17, 22 and 31, indicates the presence of, or a reduced response to therapy against, an ovarian cancer in said woman.

View all claims
  • 2 Assignments
Timeline View
Assignment View
    ×
    ×