COMPOSITIONS FOR THE INHIBITION OF GIARDIA LAMBLIA
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Abstract
The present invention relates to a composition exhibiting a bile-salt hydrolase activity for its use for the treatment or the prevention of giardiasis, said composition comprising a bile-salt hydrolase (BSH)enzyme, a bacterium able to secrete a BSH, a recombinant host cell able to secrete a BSH, or a combination thereof. The present invention also relates to the use of a composition exhibiting a BSH activity for the treatment or the prevention of giardiasis, and to a pharmaceutical composition or a food composition comprising, as an active principle, a BSH, a lactic acid bacterium able to secrete a BSH, or a recombinant host cell able to secrete a BSH.
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34 Claims
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1-14. -14. (canceled)
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15. A method of reducing the development of giardiasis in a subject, comprising administering a composition exhibiting a bile-salt hydrolase activity to a subject;
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wherein said composition is chosen from; a composition comprising at least one bile-salt hydrolase (BSH) enzyme; a composition comprising a lactic acid bacterium able to secrete at least one BSH enzyme, with the exception of Lactobacillus johnsonfi La1, Lactobacillus acidophilus, Bifidobacterium bifidum and Bifidobacterium infantis;
a composition comprising a recombinant host cell able to secrete at least one heterologous BSH enzyme; and a combination thereof; wherein said bile-salt hydrolase activity is determined by the detection of the presence of glycine or taurine liberated from conjugated bile salts, of cholic acid, of deoxycholic acid and/or of chenodeoxycholic acid. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A pharmaceutical composition, food composition, or dietary supplement, comprising as an active principle a composition exhibiting a bile-salt hydrolase activity;
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wherein said composition is chosen from; a composition comprising at least one bile-salt hydrolase (BSH) enzyme; a composition comprising a lactic acid bacterium able to secrete at least one BSH enzyme, with the exception of Lactobacillus johnsonii La1, Lactobacillus acidophilus, Bifidobacterium bifidum and Bifidobacterium infantis;
a composition comprising a recombinant host cell able to secrete at least one heterologous BSH enzyme; and a combination thereof; and a carrier; wherein said bile-salt hydrolase activity is determined by the detection of the presence of glycine or taurine liberated from conjugated bile salts, of cholic acid, of deoxycholic acid and/or of chenodeoxycholic acid. - View Dependent Claims (28)
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- 29. A method of treating giardiasis, comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising a lactic acid bacterium that secretes at least one bile salt hydrolase (BSH) enzyme, with the exception of Lactobacillus johnsonii La 1, Lactobacillus acidophilus, Bifidobacterium bifidum and Bifidobacterium infantis.
Specification