METHODS AND SYSTEMS FOR CHEMICAL EXCHANGE SATURATION TRANSFER SIGNAL MATCHING
First Claim
1. A method of determining an exchange rate between a solute material and a solvent material in chemical exchange with each other in a sample, the method comprising:
- receiving data indicative of a plurality of reference CEST scans performed on the sample and a plurality of label CEST scans performed on the sample;
determining a reference data signal and a label data signal based on the received data;
simulating a plurality of reference CEST scans on the sample to obtain a reference dictionary signal;
simulating a plurality of groups of label CEST scans on the sample to obtain a plurality of label dictionary signals, each of the plurality of label dictionary signals corresponding to a respective one of a plurality of candidate exchange rates between the solvent material and the solute material;
correcting the reference dictionary signal and each of the plurality of label dictionary signals for a magnetization transfer effect between the solvent material and the solute material;
determining a final data signal based on the reference data signal and the label data signal;
determining a plurality of final dictionary signals based on the reference dictionary signal and the plurality of label dictionary signals; and
determining the exchange rate between the solute material and the solvent material in the sample by matching the final data signal to one of the plurality of final dictionary signals.
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Accused Products
Abstract
A method of determining an exchange rate between a solute material and a solvent material in chemical exchange with each other in a sample comprises performing a plurality of CEST scans on the sample to determine a reference data signal and a label data signal; simulating a plurality of CEST scans on the sample to obtain a reference dictionary signal and a plurality of label dictionary signals, each label dictionary signal corresponding to a candidate exchange rate; correcting the reference dictionary signal and each label dictionary signal for a magnetization transfer effect; determining a final data signal based on the reference data signal and the label data signal; determining a plurality of final dictionary signals based on the reference dictionary signal and the plurality of label dictionary signals; and determining the exchange rate by matching the final data signal to one of the plurality of final dictionary signals.
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20 Claims
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1. A method of determining an exchange rate between a solute material and a solvent material in chemical exchange with each other in a sample, the method comprising:
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receiving data indicative of a plurality of reference CEST scans performed on the sample and a plurality of label CEST scans performed on the sample; determining a reference data signal and a label data signal based on the received data; simulating a plurality of reference CEST scans on the sample to obtain a reference dictionary signal; simulating a plurality of groups of label CEST scans on the sample to obtain a plurality of label dictionary signals, each of the plurality of label dictionary signals corresponding to a respective one of a plurality of candidate exchange rates between the solvent material and the solute material; correcting the reference dictionary signal and each of the plurality of label dictionary signals for a magnetization transfer effect between the solvent material and the solute material; determining a final data signal based on the reference data signal and the label data signal; determining a plurality of final dictionary signals based on the reference dictionary signal and the plurality of label dictionary signals; and determining the exchange rate between the solute material and the solvent material in the sample by matching the final data signal to one of the plurality of final dictionary signals. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method of creating an exchange rate-weighted cross-sectional image of a sample containing a solute material and a solvent material that are in chemical exchange with each other, the method comprising:
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defining a cross-sectional area of the sample, the cross-sectional area containing a plurality of pixels; determining an exchange rate between the solute material and the solvent material at each of the plurality of pixels, the determining the exchange rate at a respective pixel further comprising; receiving data indicative of a plurality of CEST scans performed on the sample; determining a data signal based on the received data; simulating a plurality of groups of CEST scans to obtain a plurality of dictionary signals, each of the plurality of dictionary signals corresponding to a respective one of a plurality of candidate exchange rates between the solute material and the solvent material; and matching the data signal to one of the plurality of dictionary signals to determine an exchange rate between the solute material and the solvent material at the respective pixel; and mapping the exchange rate of the solute material to the cross-sectional area by correlating the exchange rate at each of the plurality of pixels to a color of each of the plurality of pixels. - View Dependent Claims (19)
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20. A system for determining an exchange rate between a solute material and a solvent material in chemical exchange with each other in a sample, the system comprising:
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at least one processor; and at least one memory containing processor-executable instructions, which when executed by the at least one processor, cause the at least one processor to; receive data indicative of a plurality of reference CEST scans performed on the sample and a plurality of label CEST scans performed on the sample; determine a reference data signal and a label data signal based on the received data; simulate a plurality of reference CEST scans on the sample to obtain a reference dictionary signal; simulate a plurality of groups of label CEST scans on the sample to obtain a plurality of label dictionary signals, each of the plurality of label dictionary signals corresponding to a respective one of a plurality of candidate exchange rates between the solute material and the solvent material; correct the reference dictionary signal and each of the plurality of label dictionary signals for a magnetization transfer effect between the solute material and the solvent material; determine a final data signal based on the reference data signal and the label data signal; determine a plurality of final dictionary signals based on the reference dictionary signal and the plurality of label dictionary signals; and determine the exchange rate between the solute material and the solvent material in the sample by matching the final data signal to one of the plurality of final dictionary signals.
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Specification