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EPITOPE MAPPING METHOD

  • US 20190325985A1
  • Filed: 04/18/2019
  • Published: 10/24/2019
  • Est. Priority Date: 04/19/2018
  • Status: Active Grant
First Claim
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1. A method of mapping immune response to an immunogen, comprising:

  • immunizing a subject with an immunogen and obtaining sera from the immunized subject at multiple time intervals following immunization, wherein the sera comprises one or more immune complexes between the immunogen and serum antibodies,imaging, by electron microscopy, the sera obtained from the immunized subject in each of the time intervals, to obtain structural images of the one or more immune complexes formed between the immunogen and serum antibodies;

    mapping immune response to the immunogen by measuring differences in structural images obtained at different time intervals to simultaneously visualize diverse antibodies targeting distinct epitopes in the immunized subjects.

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