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PROCESS FOR ALIGNING TARGETED NUCLEIC ACID SEQUENCING DATA

  • US 20190325990A1
  • Filed: 01/07/2019
  • Published: 10/24/2019
  • Est. Priority Date: 01/05/2018
  • Status: Active Application
First Claim
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1. A computer-implemented method of aligning RNA comprising:

  • receiving onto a data storage unit a plurality of primer sequences and a plurality of transcript sequences from a reference genome, the transcript sequences being transcribable from the reference genome based on a gene model;

    generating, using a microprocessor, a plurality of target sequences to be amplified from a combination of the plurality of primer sequences and the plurality of transcript sequences;

    generating, using a microprocessor, a modified reference genome based on the plurality of target sequences;

    aligning, using a microprocessor, sequence reads generated from a test sample comprising RNA amplicon molecules to the modified reference genome; and

    generating an alignment profile for the test sample based on the aligning.

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