NON-IRRITATING ANTIMICROBIAL COMPOSITIONS AND METHODS OF USE

• US 20190327963A1
• Filed: 07/03/2019
• Published: 10/31/2019
• Est. Priority Date: 03/15/2013
• Status: Active Application

• Current Assignee: Purdue Research Foundation (The Trustees of Purdue University (d/b/a Purdue University))
• Original Assignee: Purdue Research Foundation (The Trustees of Purdue University (d/b/a Purdue University))
• Inventors: Li, Jianming
• Application Number:
  US16/503,067
• Publication Number:
  US 20190327963A1
• Time in Patent Office: Days
• CPC Class Codes: A01N 25/04 Dispersions, emulsions, suspoemulsions, suspension concentrates or gels foams A01N25/16
• CPC Class Codes: A01N 25/30 characterised by the surfactants
• CPC Class Codes: A01N 27/00 Biocides, pest repellants or attractants, or plant growth regulators containing hydrocarbons
• CPC Class Codes: A01N 31/02 Acyclic compounds
• CPC Class Codes: A01N 31/06 Oxygen or sulfur directly attached to a cycloaliphatic ring system
• CPC Class Codes: A01N 31/08 Oxygen or sulfur directly attached to an aromatic ring system
• CPC Class Codes: A01N 31/16 with two or more oxygen or sulfur atoms directly attached to the same aromatic ring system
• CPC Class Codes: A01N 35/02 containing aliphatically bound aldehyde or keto groups, or thio analogues thereof; Derivatives thereof, e.g. acetals
• CPC Class Codes: A01N 35/06 containing keto or thioketo groups as part of a ring, e.g. cyclohexanone, quinone; Derivatives thereof, e.g. ketals
• CPC Class Codes: A01N 37/10 Aromatic or araliphatic carboxylic acids, or thio analogues thereof; Derivatives thereof
• CPC Class Codes: A01N 37/36 containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a singly bound oxygen or sulfur atom attached to the same carbon skeleton, this oxygen or sulfur atom not being a member of a carboxylic group or of a thio analogue, or of a derivative thereof, e.g. hydroxy-carboxylic acids
• CPC Class Codes: A01N 43/16 with oxygen as the ring hetero atom
• CPC Class Codes: A01N 43/90 having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
• CPC Class Codes: A61K 31/045 Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 47/20 containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
• CPC Class Codes: A61K 47/26 Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
• CPC Class Codes: A61K 9/1075 Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers A61K9/0026 takes precedence
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 31/10 Antimycotics
• CPC Class Codes: A61P 31/12 : Antivirals
• CPC Class Codes: Y02A 50/30 : Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

Certain embodiments of the invention relate to antimicrobial emulsions for use as surface disinfectants, oral cleansers, wound dressings, agricultural and industrial sanitizers. The emulsions may include stable alcohol-free or reduced alcohol emulsions based on naturally derived plant phenolics. The emulsions may use edible surfactants at ultra-low concentrations, are non-irritating and possess rapid, high antimicrobial activity against a host of pathogenic microorganisms. Such properties permit the use of these emulsions in health care and in applications involving food preparation.

Claims

1. A non-irritating antimicrobial emulsion comprising:

thymol;

one or more additional active components selected from the group consisting of limonene, citral, methyl salicylate, eucalyptol, eugenol, carvacrol, menthol, menthone, and geraniol;

a surfactant selected from the group consisting of polysorbates and sodium laureth sulfate;

wherein the ratio of the thymol and the active components to the surfactant is from 10;

1 to 3;

1 by weight of the emulsion and a total surfactant content is less than 0.1% by weight of the emulsion;

a droplet stabilizer present in a concentration of from 0.005% to 1.0% by weight of the emulsion wherein the emulsion droplet size is from about 200 nm to about 2000 nm; and

water or a buffer solution

2. The antimicrobial emulsion of claim 1, wherein the droplet stabilizer is selected from the group consisting of xanthan gum, guar gum, carrageenan, carbomer, fenugreek gum, and myristyl myristate.

3. The antimicrobial emulsion of claim 1, wherein the droplet stabilizer is selected from the group consisting of sodium benzoate, benzoic acid, potassium sorbate, lactic acid, and malic acid.

4. The antimicrobial emulsion of claim 1, wherein the antimicrobial emulsion is effective against microorganisms selected from the group consisting of Escherichia coli, Candida albicans, Streptococcus mutans, and Actinomyces oris.

5. The antimicrobial emulsion of claim 1, wherein the antimicrobial emulsion inactivates the microorganisms by a factor of greater than or equal to a 3-log reduction within about 30 seconds.

6. The antimicrobial emulsion of claim 1, wherein the thymol and the additional active components are present at a concentration of about 0.005% to about 1%, by weight of the emulsion.

7. The antimicrobial emulsion of claim 1, further comprising one or more co-solvents selected from the group consisting of ethanol, polyethylene glycol, propylene glycol, and poloxamer, each of the co-solvents present at a concentration of 2% or less by weight of the emulsion.

8. The antimicrobial emulsion of claim 7, wherein the antimicrobial emulsion comprises a substantially self-assembling emulsion.

9. The antimicrobial emulsion of any one of claim 1 further comprising a fragrance agent.

10. The antimicrobial emulsion of any one of claim 1 further comprising a zinc compound including zinc chloride, zinc gluconate or zinc lactate

11. The antimicrobial emulsion of any one of claim 1 further comprising a chelating agent including citric acid or ethylene diamine tetraacetate.

12. The antimicrobial emulsion of claim 1 further comprising a humectant, the humectant including of one or more of sorbitol, xylitol, polyethylene glycol, or propylene glycol.

13. The antimicrobial emulsion of claim 1 further comprising an artificial or natural sweetener.

14. The antimicrobial formulation of claim 1 further comprising a spore germinating agent.

15. The antimicrobial emulsion of claim 1, wherein the antibacterial emulsion is used for at least one of a surface disinfectant, an antiseptic preparation for wounds, and an agricultural disinfectant.

16. The antimicrobial emulsion of claim 1, wherein the antibacterial emulsion is implemented in a liquid form.

17. The antimicrobial emulsion of claim 1, wherein the antibacterial emulsion is incorporated into a hydrocolloid suspension.

18. A method for reducing viable microorganisms on an object, comprising contacting an object with an effective amount of the antimicrobial emulsion of claim 1.

19. The method of claim 18, wherein the object is a hard surface, biologic tissue, or a food item.