METHOD OF MANUFACTURING NERVE ELECTRODE

• US 20190328250A1
• Filed: 03/30/2017
• Published: 10/31/2019
• Est. Priority Date: 12/19/2016
• Status: Active Application

• Current Assignee: University-Industry Cooperation Group of KyungHee University
• Original Assignee: University-Industry Cooperation Group of KyungHee University
• Inventors: KWON, Il Keun, HEO, Dong Nyoung, LEE, Dong Hyun, LEE, Sang Jin, HEO, Min
• Application Number:
  US16/471,354
• Publication Number:
  US 20190328250A1
• Time in Patent Office: Days
• CPC Class Codes: A61B 2562/0215 Silver or silver chloride containing
• CPC Class Codes: A61B 2562/125 characterised by the manufacture of electrodes
• CPC Class Codes: A61B 2562/164 the sensor is mounted in or on a conformable substrate or carrier
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/0556 Cuff electrodes
• CPC Class Codes: B41M 3/006 Patterns of chemical products used for a specific purpose, e.g. pesticides, perfumes, adhesive patterns; use of microencapsulated material; Printing on smoking articles
• CPC Class Codes: B41M 5/0023 Digital printing methods characterised by the inks used inks per se C09D11/00
• CPC Class Codes: B41M 5/0047 by ink-jet printing
• CPC Class Codes: B41M 5/0064 on plastics, horn, rubber, or other organic polymers
• CPC Class Codes: D01D 5/0007 Electro-spinning non-woven fabrics produced by electro-spinning D04H1/728
• CPC Class Codes: D01D 5/003 the material being a polymer solution or dispersion D01D5/0053 takes precedence
• CPC Class Codes: D01F 6/74 from polycondensates of cyclic compounds, e.g. polyimides, polybenzimidazoles
• CPC Class Codes: D06M 10/10 Macromolecular compounds
• CPC Class Codes: D06M 11/83 with metals; with metal-generating compounds, e.g. metal carbonyls; Reduction of metal compounds on textiles
• CPC Class Codes: D06M 15/63 containing sulfur in the main chain, e.g. polysulfones
• CPC Class Codes: D06M 23/08 Processes in which the treating agent is applied in powder or granular form adhesives for multi-layer textile fabrics D06M17/00
• CPC Class Codes: D06P 1/44 using insoluble pigments or auxiliary substances, e.g. binders
• CPC Class Codes: D06P 5/30 Ink jet printing
• CPC Class Codes: D10B 2509/00 Medical; Hygiene

Abstract

The present invention relates to a method of manufacturing a nerve electrode in which a conductive ink is inkjet printed on an electrospun polyimide fibrous sheet; and a nerve electrode manufactured by the manufacturing method.

Claims

1. A method of manufacturing a nerve electrode, the method comprising the steps of:

1) manufacturing a poly(amic acid) fibrous sheet by electrospinning poly(amic acid);

2) manufacturing a polyimide fibrous sheet by heat-treating the poly(amic acid) fibrous sheet;

3) thermally compressing the polyimide fibrous sheet;

4) inkjet printing a conductive ink on the polyimide fibrous sheet thermally compressed in Step

     3); and

5) heat-treating the polyimide fibrous sheet on which the conductive ink is inkjet printed in Step

     4).

2. The method of claim 1, further comprising:

6) a step of applying poly(3,4-ethylene dioxythiophene)/poly(styrenesulfonate) (PEDOT/PSS) on the inkjet printed conductive ink by an electrochemical polymerization method.

3. The method of claim 1, wherein the poly(amic acid) in Step 1) is synthesized by polycondensation of pyromellitic dianhydride (PMDA) and 4,4′

-oxydianiline in N,N-dimethylacetamide.

4. The method of claim 1, wherein the electrospinning in Step 1) is performed at a voltage of 10 kV to 40 kV.

5. The method of claim 1, wherein the heat treatment in Step 2) comprises applying 250°

C. to 500°

C. heat to the poly(amic acid) fibrous sheet.

6. The method of claim 1, wherein the heat treatment in Step 2) is performed for 30 minutes

7. The method of claim 1, wherein the thermal compression in Step 3) compresses the polyimide fibrous sheet at a temperature of 80°

C. to 140°

C.

8. The method of claim 1, wherein the thermal compression in Step 3) thermally compresses the polyimide fibrous sheet under a pressure of 500,000 N/m2 to 1,000,000 N/m2.

9. The method of claim 1, wherein the conductive ink in Step 4) comprises any one or more metal nanoparticles selected from the group consisting of a silver nanoparticle, a gold nanoparticle, a copper nanoparticle, an aluminum nanoparticle, a platinum nanoparticle, a titanium nanoparticle, an iridium nanoparticle, and an indium nanoparticle.

10. The method of claim 9, wherein the metal nanoparticle is a silver nanoparticle.

11. The method of claim 1, wherein the heat treatment in Step 5) comprises applying 140°

C. to 220°

C. heat on the inkjet printed conductive ink.

12. The method of claim 1, wherein the heat treatment in Step 5) is performed for 30 minutes to 6 hours.

13. The method of claim 1, further comprising a step of containing an anti-fibrotic drug by bringing the nerve electrode into contact with a solution in which the anti-fibrotic drug is dissolved.

14. A nerve electrode manufactured by the method of claim 1.

15. The nerve electrode of claim 14, wherein polyimide fibers comprised in the nerve electrode have a diameter of 600 nm to 1,200 nm.

16. The nerve electrode of claim 14, wherein a polyimide fibrous sheet comprised in the nerve electrode has a porosity of 60 vol % to 90 vol %.

17. The nerve electrode of claim 14, further comprising an anti-fibrotic drug.

18. The nerve electrode of claim 14, wherein the nerve electrode comprises the anti-fibrotic drug in an amount of 0.1 wt % to 1 wt % based on a total weight of the total nerve electrode.

19. The nerve electrode of claim 18, where in the anti-fibrotic drug is one or drugs selected from the group consisting of tranilast, mitomycin, pirfenidone, ibuprofen, aztreonam, tobramycin, and ciprofloxacin

20. The nerve electrode of claim 14, wherein the nerve electrode is for sensing nerve signals.

21. The nerve electrode of claim 20, wherein the sensing of nerve signals is sensing of nerve signals of a nervous system selected from the group consisting of an electrocardiograph, an electroencephalograph, an electromyograph, an electroretinograph, and a transcutaneous nerve system.