STABLE REDOX COMPOSITIONS AND METHODS OF USE

• US 20190328632A1
• Filed: 04/11/2019
• Published: 10/31/2019
• Est. Priority Date: 12/22/2017
• Status: Active Grant

• Current Assignee: Reoxcyn, LLC
• Original Assignee: Reoxcyn, LLC
• Inventors: Richards, Kurt
• Granted Patent: US 11,039,992 B2
• Time in Patent Office: Days
• CPC Class Codes: A61K 2800/83 Electrophoresis; Electrodes; Electrolytic phenomena
• CPC Class Codes: A61K 47/02 Inorganic compounds
• CPC Class Codes: A61K 47/34 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers A61K47/10 takes precedence
• CPC Class Codes: A61K 8/042 Gels
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 8/20 Halogens; Compounds thereof
• CPC Class Codes: A61K 8/24 Phosphorous; Compounds thereof
• CPC Class Codes: A61K 8/26 Aluminium; Compounds thereof
• CPC Class Codes: A61K 8/891 saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
• CPC Class Codes: A61K 8/965 of inanimate origin
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61K 9/0053 Mouth and digestive tract, i.e. intraoral and peroral administration rectal administration A61K9/0031
• CPC Class Codes: A61K 9/0095 Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches A61K9/0007 takes precedence; eatable gels or foams A61K9/0056; oral mucosa adhesive forms A61K9/006
• CPC Class Codes: A61K 9/06 Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels composition of ointments, creams or gels A61K47/00
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

Described herein are compositions that include a saline solution and reactive oxygen species. Specifically, the composition may include a saline solution, reactive oxygen species, an emollient, and a pH modifier. Also provided is a gel composition that includes a rheology agent. Also provided are methods of making and using the compositions.

Claims

1-21. -21. (canceled)

22. A method of making a composition, comprising:

providing a saline solution, wherein the saline solution includes a salt and the salt is an unprocessed salt;

electrolyzing the saline solution;

mixing an emollient with the saline solution; and

mixing a rheology agent with the saline solution.

23. The method of claim 22, further comprising:

preparing an ultra-pure homogeneous solution of sodium chloride in water;

controlling temperature and flow through a set of inert catalytic electrodes; and

modulating an electrolytic process.

24. A composition, comprising:

an electrolyzed saline solution;

a reactive oxygen species;

an emollient; and

a pH modifier;

the composition comprising an osmolality measurement value between about 0.5 and 100 mOsm/kg.

25. The composition of claim 24, wherein the osmolality measurement value is about 3 to 5 mOsm/kg.

26. The composition of claim 24, wherein the electrolyzed saline solution comprises salt present in an amount of 0.05%, wherein the reactive oxygen species is sodium hypochlorite present in an amount of 72 ppm of, wherein the emollient is silicone polymer present in an amount of 5% wt/vol, wherein the pH modifier is sodium phosphate monobasic present in an amount of 0.3% wt/vol, and further comprising sodium magnesium silicate present in an amount of 3.25% wt/vol.

27. The composition of claim 24, wherein the electrolyzed saline solution is present in an amount of 94.628% final wt/vol and comprises salt in an amount 0.05%, wherein the emollient comprises silicone polymer present in an amount of 5% final wt/vol, wherein the reactive oxygen species comprises sodium hypochlorite present in an amount of 0.072% final wt/vol, and wherein the pH modifier is sodium phosphate monobasic present in an amount of 0.3% final wt/vol.

28. The composition of claim 24, wherein the electrolyzed saline solution is present in an amount of 91.378% final wt/vol and comprises salt in an amount of 0.05%, wherein the emollient comprises silicone polymer present in an amount of 5% final wt/vol, wherein the reactive oxygen species comprises sodium hypochlorite present in an amount of 0.072% final wt/vol, wherein the pH modifier is sodium phosphate monobasic present in an amount of 0.3% final wt/vol, and further comprising sodium magnesium silicate present in an amount of 3.25% final wt/vol, wherein the composition is formulated as a gel.

29. The composition of claim 24 further comprising:

sodium magnesium silicate present in an amount of about 3% wt/vol of; and

an additive selected from the group consisting of moisturizers, humectants, pigments, dyes, pearlescent compounds, nacreous pigments, bismuth oxychloride coated mica, titanium dioxide coated mica, colorants, fragrances, biocides, preservatives, lipolytic agents, diuretics, xanthines, alpha hydroxyl acids, antioxidants, lymphatic drainage agents, antiperspirant agents, exfoliants, hormones, enzymes, medicinal compounds, vitamins, minerals, electrolytes, alcohols, polyols, polypropylene glycol, retinoids, retinol, polyisobutene, polyoxyethylene, behenic acid, behenyl, sugar-alcohols, absorbing agents for ultraviolet radiation, botanical extracts, surfactants, silicone oils, organic oils, waxes, alkaline or acidic or buggering agents, film formers, thickening agents, hyaluronic acid, fumed silica, hydrated silica, talc, kaolin, starch, modified starch, mica, nylon, clay, bentonite, organo-modified clays, and combinations thereof,

wherein the composition is formulated as a topical formulation.

30. A method, comprising:

topically applying the composition of claim 29 to a subject.

31. A composition, comprising:

an electrolyzed saline solution, the electrolyzed saline comprising a salt, and the salt comprising;

aluminum in an amount of 32.473 ppm to 241.700 ppm,

calcium in an amount of 1290 ppm to 2101 ppm,

iron in an amount of 23.292 ppm to 141.400 ppm,

lead in an amount of 0.077 ppm to 0.210 ppm,

magnesium in an amount of 217.9 ppm to 1944.0 ppm,

potassium in an amount of 149.3 ppm to 1728.0 ppm, and

strontium in an amount of 11.251 ppm to 32.223 ppm;

a reactive oxygen species;

an emollient; and

a pH modifier.