NANOSPUN HEMP-BASED MATERIALS

• US 20190328678A1
• Filed: 04/26/2019
• Published: 10/31/2019
• Est. Priority Date: 04/27/2018
• Status: Active Grant

• Current Assignee: Thomas Jefferson University (Main Line Health System)
• Original Assignee: Thomas Jefferson University (Main Line Health System)
• Inventors: Sunderland, Mark
• Granted Patent: US 11,173,128 B2
• Time in Patent Office: Days
• CPC Class Codes: A61K 31/05 Phenols cannabinoids A61K31/658
• CPC Class Codes: A61K 9/70 Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug hollow drug-filled fibres A61K9/0092

Abstract

An antibacterial composite material comprising at least 10% of a hemp oil, said hemp oil comprising CBD at a concentration of at least 10 mg/ml and a polymer formed by a process wherein said hemp oil and said polymer are dissolved into a solvent and said solvent is expressed through a spinneret, wherein a voltage is applied at up to 100 kV, wherein the solvent is pressed through the spinneret and forming the antibacterial composite material on a collector.

Claims

1. A method of manufacturing a composite material comprising of extracting a portion of oil from a hemp plant to form an extracted hemp oil;

dissolving the extracted hemp oil into a nonaqueous solvent;

dissolving a second material into said nonaqueous solvent;

extruding the material having both the extracted hemp oil and second material into a nanospun fiber.

2. The method of claim 1, wherein the extracted hemp oil comprises at least 10 mg/ml CBD, and a carrier oil.

3. The method of claim 1, wherein the nonaqueous solvent is acetone.

4. The method of claim 1, wherein the portion of extracted hemp oil comprises between 0.1 and 50% of the total weight of the composite material.

5. The method of claim 1, wherein the portion of extracted hemp oil comprises between 5 and 25% of the total weight of the composite material.

6. The method of claim 1, wherein the portion of extracted hemp oil comprises between 5 and 15% of the total weight of the composite material.

7. The method of claim 1, further comprising a third component which is effective in reducing the population of gram-negative bacteria when such gram-negative bacteria contact said third component.

8. The method of claim 1, wherein the extracted hemp oil comprises at least 20 mg/ml CBD.

9. (canceled)

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17. An antibacterial composite material comprising at least 10% of a hemp oil comprising CBD at a concentration of at least 10 mg/ml and a polymer formed by a process wherein said hemp oil and said polymer are dissolved into a solvent and said solvent is expressed through a spinneret, wherein a voltage is applied at up to 100 kV, wherein the solvent is pressed through the spinneret and forming the antibacterial composite material on a collector.

18. The antibacterial composite material of claim 17, wherein the polymer is selected from a biodegradable polymer, a non-biodegradable polymer, or combinations thereof.

19. The antibacterial composite material of claim 17 comprising at least a second oil, said at least second oil selected from the group consisting of:

allspice, angelica, anise, basil, bay leaf, benzoin, bergamot, birch, bitter almond, black pepper, boldo, buchu, cajuput, calamus, chamomile, camphor, caraway, cardamom, carrot seed, cassia, catnip, cedarwood, chrysanthemum, cinnamon, citronella, coconut, clary sage, clove, coconut, coriander, cumin, cypress, davana, dill, elemi, eucalyptus, fennel, frankincense, galbanum, geranium, ginger, grapefruit, helichrysum, hemp, hyssop, jasmine, juniper, lavandin, lavender, lemon, lemongrass, lime, mandarin, manuka, marjoram, MCT (medium chain triglycerides) oil, melissa, mugwort, mullein, mustard, myrrh, myrtle, neroli, niaouli, nutmeg, oakmoss, orange, oregano, palm, palma rosa, parsley, patchouli, pennyroyal, peppermint, petitgrain, pimento, pine, ravensara, rose, rosemary, rosewood, rue, sage, sandalwood, spearmint, spikenard, tagetes, tangerine, tansy, tarragon, tea tree, thuja, thyme, tuberose, vanilla, vetiver, wintergreen, wormwood, yarrow, ylang, and combinations thereof.

20. The antibacterial composite material of claim 17, wherein said polymer is selected from the group consist of:

polylactic acid, polyglycolide, polyglycolic acid, polylactide, polyhydroxobutyrate, chitosan, hyaluronic acid, and hydrogels;

poly(2-hydroxyethyl-methacrylate), poly(ethylene glycol), chitosan, acetate, rubber, polyethylene, polystyrene, polycarbonate, acrylic resins, polyurethane, polypropylene, polymethylmethacrylate, poly tetrafluoro ethylene, thermoplastic polyurethane, as well as those based on fluorocarbons and certain hydrocarbon polymers are typically non-biodegradable; and

combinations thereof.

21. The antibacterial composite material of claim 17, wherein the solvent is acetone.

22. The antibacterial composite material of claim 17, further comprising a third component which is effective in reducing the population of gram-negative bacteria when such gram-negative bacteria contact said third component.

23. The antibacterial composite material of claim 17, wherein the extracted hemp oil comprises at least 20 mg/ml CBD.

24. The antibacterial composite material of claim 19, having arthropod repellant properties