SUPER-OXIDE DISMUTASE MIMETICS

• US 20190328704A1
• Filed: 07/11/2019
• Published: 10/31/2019
• Est. Priority Date: 11/14/2007
• Status: Abandoned Application

• Current Assignee: Galera Labs, LLC
• Original Assignee: Galera Labs, LLC
• Inventors: RILEY, Dennis P.
• Application Number:
  US16/509,131
• Publication Number:
  US 20190328704A1
• Time in Patent Office: Days
• CPC Class Codes: A61K 31/395 having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
• CPC Class Codes: A61K 31/4353 ortho- or peri-condensed with heterocyclic ring systems
• CPC Class Codes: A61K 31/555 containing heavy metals, e.g. hemin, hematin, melarsoprol
• CPC Class Codes: A61P 11/06 Antiasthmatics
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: A61P 9/12 Antihypertensives
• CPC Class Codes: C07D 259/00 Heterocyclic compounds containing rings having more than four nitrogen atoms as the only ring hetero atoms
• CPC Class Codes: C07D 471/08 Bridged systems

Abstract

The present invention relates to compounds which are effective as catalysts for dismutating superoxide and, more particularly, the manganese or iron complexes of substituted, unsaturated heterocyclic 10-membered macrocyclic complexes that catalytically dismutate superoxide. It also relates to methods of using these complexes to reduce the concentration or the effects of superoxide, pharmaceutical compositions comprising these compounds or their metal complexes, and methods of treating conditions associated with excessive superoxide activity.

Claims

1. A compound of formula (2b):