SYNERGISTIC COMPOSITION FOR INHIBITING ADVANCED GLYCATION END PRODUCT CROSSLINKING

• US 20190328710A1
• Filed: 04/26/2019
• Published: 10/31/2019
• Est. Priority Date: 04/28/2018
• Status: Abandoned Application

• Current Assignee: H2 Water Technologies Ltd.
• Original Assignee: H2 Water Technologies Ltd.
• Inventors: TARNAVA, Alexander, HOLLAND, Richard James
• Application Number:
  US16/395,689
• Publication Number:
  US 20190328710A1
• Time in Patent Office: Days
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/05 Phenols cannabinoids A61K31/658
• CPC Class Codes: A61K 31/12 Ketones
• CPC Class Codes: A61K 31/145 having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2) isothiourea A61K31/155
• CPC Class Codes: A61K 31/216 of acids having aromatic rings, e.g. benactizyne, clofibrate
• CPC Class Codes: A61K 31/381 having five-membered rings
• CPC Class Codes: A61K 31/417 Imidazole-alkylamines, e.g. histamine, phentolamine
• CPC Class Codes: A61K 31/505 Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
• CPC Class Codes: A61K 36/45 Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry

Abstract

The invention provides a composition or kit including two, three, or all of rosmarinic acid; alpha-lipoic acid; benfotiamine; carnosine; and optionally vitamin B6. The compositions and kits are useful for reducing AGE crosslinking or the visible signs of aging.

Claims

1. A composition comprising rosmarinic acid;

alpha-lipoic acid;

carnosine; and

benfotiamine.

2. The composition of claim 1, wherein the amount of rosmarinic acid is 20-2000 mg.

4. The composition of claim 1, wherein the amount of alpha-lipoic acid is 30-3000 mg.

6. The composition of claim 1, wherein the amount of carnosine is 50-5000 mg.

8. The composition of claim 1, wherein the amount of benfotiamine is 25-2500 mg.

10. The composition of claim 1, further comprising one or more of vitamin C;

blueberry and/or bilberry extract;

resveratrol;

curcumin;

taurine;

vitamin B6;

clove; and

/or cinnamon.

11. The composition of claim 10, wherein the amount of vitamin C is 10-1000 mg;

wherein the amount of curcumin is 80-8000 mg;

wherein the amount of taurine is 40-4000 mg;

wherein the amount of blueberry and/or bilberry extract is 30-3000 mg;

wherein the amount of resveratrol is 25-2500 mg.

43. A method of reducing AGE crosslinking or the visible signs of aging, the method comprising administering an effective amount of a composition of claim 1 to a subject in need thereof.

44. The composition of claim 1, wherein the amount of rosmarinic acid is about 200 mg;

the amount of alpha-lipoic acid is about 300 mg;

the amount of carnosine is about 500 mg;

or the amount of benfotiamine is about 250 mg.

45. The composition of claim 10, wherein the amount of vitamin C is about 100 mg;

the amount of curcumin is about 800 mg;

the amount of taurine is about 400 mg;

the amount of blueberry and/or bilberry extract is about 300 mg;

or the amount of resveratrol is about 250 mg.

3. (canceled)

5. (canceled)

7. (canceled)

9. (canceled)

12-21. -21. (canceled)

22. A kit comprising:

rosmarinic acid;

alpha-lipoic acid;

carnosine; and

benfotiamine, wherein the rosmarinic acid;

alpha-lipoic acid;

carnosine; and

benfotiamine are formulated in at least two compositions.

23. The kit of claim 22, wherein the amount of rosmarinic acid is 20-2000 mg.

25. The kit of claim 22, wherein the amount of alpha-lipoic acid is 30-3000 mg.

27. The kit of claim 22, wherein the amount of carnosine is 50-5000 mg.

29. The kit of claim 22, wherein the amount of benfotiamine is 25-2500 mg.

31. The kit of claim 22, further comprising one or more of vitamin C;

blueberry and/or bilberry extract;

resveratrol;

curcumin;

taurine;

vitamin B6;

clove; and

/or cinnamon.

32. The kit of claim 31, wherein the amount of vitamin C is 10-1000 mg;

wherein the amount of curcumin is 80-8000 mg;

wherein the amount of taurine is 40-4000 mg;

wherein the amount of blueberry and/or bilberry extract is 30-3000 mg;

or wherein the amount of resveratrol is 25-2500 mg.

46. The kit of claim 22, wherein the amount of rosmarinic acid is about 200 mg;

the amount of alpha-lipoic acid is about 300 mg;

the amount of carnosine is about 500 mg;

or the amount of benfotiamine is about 250 mg.

47. The kit of claim 31, wherein the amount of vitamin C is about 100 mg;

the amount of curcumin is about 800 mg;

the amount of taurine is about 400 mg;

the amount of blueberry and/or bilberry extract is about 300 mg;

or the amount of resveratrol is about 250 mg.

24. (canceled)

26. (canceled)

28. (canceled)

30. (canceled)

33-42. -42. (canceled)