LOW DOSE COMPOSITIONS OF ARAMACHOL SALTS
First Claim
Patent Images
1. A pharmaceutical composition in unit dosage form comprising a therapeutically effective amount of a salt of 3β
- -arachidylamido-7α
,12α
-dihydroxy-5β
-cholan-24-oic acid (Aramchol) with an amine, in which the Aramchol component is present in an amount of about 10 to 400 mg based on the weight of Aramchol free acid; and
optionally at least one pharmaceutically acceptable carrier, diluent, vehicle or excipient.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention relates to salts of arachidyl amido cholanoic acid (Aramchol), pharmaceutical compositions comprising Aramchol salts, methods for their preparation, and methods of use thereof in medical treatment.
1 Citation
34 Claims
-
1. A pharmaceutical composition in unit dosage form comprising a therapeutically effective amount of a salt of 3β
- -arachidylamido-7α
,12α
-dihydroxy-5β
-cholan-24-oic acid (Aramchol) with an amine, in which the Aramchol component is present in an amount of about 10 to 400 mg based on the weight of Aramchol free acid; and
optionally at least one pharmaceutically acceptable carrier, diluent, vehicle or excipient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 24, 25, 26, 27, 28, 29, 30, 31)
- -arachidylamido-7α
-
23. A method of treating a condition associated with fatty liver in a human subject in need thereof, comprising the step of administering to the subject a pharmaceutical composition in unit dosage form comprising a therapeutically effective amount of a salt of 3β
- -arachidylamido-7α
,12α
-dihydroxy-5β
-cholan-24-oic acid (Aramchol) with an amine, in which the Aramchol component is present in an amount of about 10 to 400 mg, based on the weight of Aramchol free acid; and
optionally at least one pharmaceutically acceptable carrier, diluent, vehicle or excipient.
- -arachidylamido-7α
-
32. A method of treating a disease or condition amenable for treatment by 3β
- -arachidylamido-7α
,12α
-dihydroxy-5β
-cholan-24-oic acid (Aramchol) in a human subject in need thereof, comprising the step of administering to the subject a pharmaceutical composition in unit dosage form comprising a therapeutically effective amount of a salt of Aramchol with an amine, in which the Aramchol component is present in an amount of about 10 to 400 mg, based on the weight of Aramchol free acid; and
optionally at least one pharmaceutically acceptable carrier, diluent, vehicle or excipient. - View Dependent Claims (33)
- -arachidylamido-7α
-
34-37. -37. (canceled)
Specification