USE OF PROBIOTICS IN THE TREATMENT AND/OR PREVENTION OF PSORIASIS

• US 20190328799A1
• Filed: 03/21/2017
• Published: 10/31/2019
• Est. Priority Date: 03/21/2016
• Status: Active Grant

• Current Assignee: Biopolis SL (Archer Daniels Midland Company)
• Original Assignee: Biopolis SL (Archer Daniels Midland Company), Bionou Research, S.L., Korott, S.L.
• Inventors: NAVARRO LOPEZ, Vicente Manuel, RAMIREZ BOSCA, Ana Adela, PEREZ ORQUIN, Jose Manuel, RAMON VIDAL, Daniel, GENOVES MARTINEZ, Salvador, CHENOLL CUADROS, MarIa Empar, CODONER CORTES, Francisco
• Granted Patent: US 10,912,802 B2
• Time in Patent Office: Days
• CPC Class Codes: A23K 10/18 of live microorganisms
• CPC Class Codes: A23L 33/135 Bacteria or derivatives thereof, e.g. probiotics
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2400/175 Rhamnosus
• CPC Class Codes: A23V 2400/515 Animalis
• CPC Class Codes: A23V 2400/531 Lactis
• CPC Class Codes: A23V 2400/533 Longum
• CPC Class Codes: A61K 2035/115 Probiotics
• CPC Class Codes: A61K 35/741 Probiotics probiotic yeast, e.g. saccharomyces A61K36/06
• CPC Class Codes: A61K 35/745 Bifidobacteria
• CPC Class Codes: A61K 35/747 Lactobacilli, e.g. L. acidophilus or L. brevis
• CPC Class Codes: A61K 36/064 Saccharomycetales, e.g. baker's yeast
• CPC Class Codes: A61P 17/06 Antipsoriatics

Abstract

The present invention is intended for the use of a probiotic composition comprising Bifidobacterium animalis subs. lactis (B. lactis), Bifidobacterium longum and Lactobacillus rhamnosus, in particular the strains B. lactis CECT 8145, B. longum ES1 CECT 7347 and/or L. rhamnosus CECT 8361, in the treatment and/or prevention of psoriasis outbreaks or psoriasis.

Claims

1-12. -12. (canceled)

13. A probiotic composition comprising microorganisms of Bifidobacterium animalis subs. lactis (B. lactis), Bifidobacterium longum and Lactobacillus rhamnosus, wherein the concentration of B. longum with respect to the total concentration of microorganisms present in the composition is at least 30%.

14. The probiotic composition according to claim 13, wherein B. lactis is B. lactis CECT 8145, B. longum is B. longum ES1 CECT 7347 and/or L. rhamnosus is L. rhamnosus CECT 8361.

15-16. -16. (canceled)

17. A method for the treatment or prevention of psoriasis outbreaks or psoriasis comprising administering to a subject in need thereof an effective amount of a probiotic composition comprising Bifidobacterium animalis subsp. lactis (B. lactis), Bifidobacterium longum and Lactobacillus rhamnosus.

18. The method according to claim 17, wherein B. lactis is B. lactis CECT 8145 is, B. longum is B. longum ES1 CECT 7347 and/or L. rhamnosus is L. rhamnosus CECT 8361.

19. The method according to claim 17, wherein the psoriasis outbreak or psoriasis is selected from the group consisting of plaque psoriasis, palmar-plantar psoriasis, scalp psoriasis, nail psoriasis, psoriasis on the face, psoriasis in the folds, guttate psoriasis, erythrodermic psoriasis and pustular psoriasis.

20. The method according to claim 17, wherein the probiotic composition is a pharmaceutical composition or a nutritional composition.

21. The method according to claim 20, wherein the pharmaceutical composition comprises a pharmaceutically acceptable carrier and/or an excipient.

22. The method according to claim 20, wherein the pharmaceutical composition is formulated for administration in liquid form or in solid form.

23. The method according to claim 22, wherein the solid formulation is selected from the group consisting of tablets, lozenges, sweets, chewable tablets, chewing gum, capsules, sachets, powders, granules, coated particles or coated tablets, tablets and gastro-resistant tablets and capsules and dispersible strips and films.

24. The method according to claim 22, wherein the liquid formulation is selected from the group consisting of oral solutions, suspensions, emulsions and syrups.

25. The method according to claim 20, wherein the nutritional composition is a food or a nutritional supplement.

26. The method according to claim 25, wherein the food is selected from the group consisting of fruit or vegetable juices, ice cream, infant formula, milk, yogurt, cheese, fermented milk, milk powder, cereals, baked goods, milk-based products, meat products and beverages.

27. The method according to claim 17, wherein the composition further comprises a microorganism selected from the group consisting of Lactobacillus sp., Streptococcus sp., Bifidobacterium sp., Saccharomyces sp., Kluyveromyces sp. and combinations thereof.

28. The method according to claim 17, wherein the total concentration of microorganisms of the strains B. lactis, L. rhamnosus and B. longum in the composition is between 10³ and 10¹² cfu.

29. The method according to claim 17, wherein the concentration of B. longum with respect to the total concentration of microorganisms present in the composition is at least 30%.