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METHOD OF TREATING PATIENTS WITH HEPATORENAL SYNDROME TYPE 1

  • US 20190328831A1
  • Filed: 05/14/2019
  • Published: 10/31/2019
  • Est. Priority Date: 10/24/2014
  • Status: Abandoned Application
First Claim
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1. A method for treating HRS-1, the method comprising:

  • diagnosing a plurality of patients as having HRS-1;

    determining that a first and a second patient of the plurality do not have overt sepsis, septic shock, or uncontrolled infection;

    testing the first and second patients to determine whether each meets each of the following three criteria (i)-(iii);

    (i) a white blood cell count either less than 4,000 cells/mm3 or greater than 12,000 cells/mm3,(ii) a heart rate of greater than 90 beats per minute, and(iii) either (a) a partial pressure of carbon dioxide in the blood (PaCO2) of <

    32 mmHg or (b) a blood bicarbonate (HCO3) level of <

    23 mmol/L or (c) tachypnea with more than 20 breaths per minute;

    determining that the first patient meets at least two of the three criteria;

    determining that, because the first patient meets at least two of the three criteria, the first patient'"'"'s renal function is more likely to improve upon treatment with terlipressin than if the first patient exhibited only one or none of the three criteria;

    initiating administration of terlipressin to the first patient within two days of the determination that the first patient meets at least two of the three criteria, wherein the terlipressin is administered as an IV in an amount effective to reduce the first patient'"'"'s serum creatinine level by at least 1.0 mg/dL;

    determining that the second patient meets only one or none of the three criteria;

    determining that, because the second patient does not meet at least two of the three criteria, the second patient'"'"'s renal function is less likely to respond to treatment with terlipressin than if the second patient exhibited at least two of the three criteria; and

    excluding the second patient from treatment with terlipressin.

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