IMMUNOTHERAPEUTIC PRODUCT AND MDSC MODULATOR COMBINATION THERAPY
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention provides an immunotherapeutic composition for use in combination with one or more MDSC (Myeloid-derived suppressor cells) modulator(s) and a kit of parts comprising such components as well as methods using such components in combination. The invention also provides the use of Phosphodiesterase-5 (PDE5) inhibitors for reversing immunosuppression in chronic infectious diseases. The invention is of very special interest in treating or preventing diseases, especially chronic infectious diseases such as hepatitis B.
-
Citations
57 Claims
-
1-25. -25. (canceled)
- 26. A combination comprising at least (a) a composition comprising a therapeutically effective amount of an immunotherapeutic product and at least (b) one or more MDSC modulator(s).
- 41. A method for treating or preventing a disease or a pathologic condition in a subject in need thereof or for treating a subject having a condition that would benefit from upregulation of the immune response, comprising administering to said subject a therapeutically effective amount of a combination comprising at least (a) a composition comprising a therapeutically effective amount of an immunotherapeutic product and at least (b) one or more MDSC modulator(s).
- 53. A method for decreasing the levels of HBsAg and/or HBV viral load in the serum of a subject diagnosed as having an HBV infection, comprising administering to said subject a therapeutically effective amount of a combination comprising at least (a) a composition comprising a therapeutically effective amount of an immunotherapeutic product and at least (b) one or more MDSC modulator(s).
- 55. A method for treating or preventing a chronic infectious disease in a subject in need thereof or for reversing immunosuppression in a subject having a chronic infectious disease, comprising administering to said subject a PDE-5 inhibitor.
Specification