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Method for Preparing Anti-Bacterial Surface on Medical Material Surface

  • US 20190328939A1
  • Filed: 11/14/2017
  • Published: 10/31/2019
  • Est. Priority Date: 01/05/2017
  • Status: Active Grant
First Claim
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1. A method for preparing an anti-bacterial surface on a medical material surface, comprising:

  • (1) conducting chemical graft of amino silane after performing oxygen plasma pretreatment to the medical material surface and then reacting the medical material with an amino silane-grafted surface with an acyl compound, obtaining a medical material with an initiator-modified surface for atom transfer radical polymerization;

    (2) placing the medical material with the initiator-modified surface obtained by step (1) into an mixed solution for anti-adhesion monomer radical polymerization for a graft polymerization reaction, obtaining a medical material with an anti-adhesion polymer brush-modified surface;

    (3) placing the medical material with the anti-adhesion polymer brush-modified surface obtained by step (2) into an azide compound-containing dimethylformamide solution, obtaining a medical material with an azide surface;

    (4) placing the medical material with the azide surface prepared in step (3) into an anti-bacterial agent click solution for a click reaction, obtaining an anti-adhesion polymer layer—

    and anti-bacterial agent layer-comodified anti-bacterial surface.

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