EMBOLIZATION MICROCATHETER

• US 20190329000A1
• Filed: 06/13/2019
• Published: 10/31/2019
• Est. Priority Date: 01/09/2015
• Status: Abandoned Application

• Current Assignee: Accurate Medical Therapeutics Ltd.
• Original Assignee: Accurate Medical Therapeutics Ltd.
• Inventors: TAL, Michael Gabriel, MILLER, Eran
• Application Number:
  US16/439,899
• Publication Number:
  US 20190329000A1
• Time in Patent Office: Days
• CPC Class Codes: A61B 17/12109 in a blood vessel
• CPC Class Codes: A61B 17/12186 liquid materials adapted to be injected
• CPC Class Codes: A61B 2017/00345 Micromachines, nanomachines, microsystems
• CPC Class Codes: A61B 2017/00884 enhancing wound closure
• CPC Class Codes: A61B 2017/00893 pharmaceutically effective
• CPC Class Codes: A61B 2017/1205 Introduction devices
• CPC Class Codes: A61M 2025/0024 Expandable catheters or sheaths
• CPC Class Codes: A61M 2025/0042 Microcatheters, cannula or the like having outside diameters around 1 mm or less
• CPC Class Codes: A61M 2025/0057 Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings
• CPC Class Codes: A61M 2025/0073 Tip designed for influencing the flow or the flow velocity of the fluid, e.g. inserts for twisted or vortex flow general flow characteristics A61M2206/10
• CPC Class Codes: A61M 2025/0079 Separate user-activated means, e.g. guidewires, guide tubes, balloon catheters or sheaths, for sealing off an orifice, e.g. a lumen or side holes, of a catheter
• CPC Class Codes: A61M 2025/0096 being laterally outward extensions or tools, e.g. hooks or fibres
• CPC Class Codes: A61M 2205/7545 for solid matter, e.g. microaggregates
• CPC Class Codes: A61M 25/0021 characterised by the form of the tubing A61M25/0054 takes precedence
• CPC Class Codes: A61M 25/0054 with regions for increasing flexibility
• CPC Class Codes: A61M 25/0067 characterised by the distal end, e.g. tips A61M25/0054, A61M25/04 take precedence; balloon catheters A61M25/10
• CPC Class Codes: A61M 25/0068 Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
• CPC Class Codes: A61M 25/007 Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
• CPC Class Codes: A61M 25/0074 Dynamic characteristics of the catheter tip, e.g. openable, closable, expandable or deformable
• CPC Class Codes: A61M 25/0075 Valve means
• CPC Class Codes: A61M 31/005 : for contrast media
• CPC Class Codes: A61M 5/007 : for contrast media

Abstract

Microcatheter for delivering a substance (e.g., infusion agent including embolization material and/or contrast enhancing material) in a small blood vessel towards a target bodily part. Includes a single lumen surrounded by tubular wall having outer diameter and opened at both ends; tubular wall proximal portion is connectable to a pressure source and reservoir containing infusion agent, and tubular wall distal portion ends with a tip; the tubular wall distal portion includes an infusion agent flow disruption section configured to disrupt passage therethrough of incoming retrograded flow of infusion agent, during continuous delivery of infusion suspension from the reservoir to the tip. Disclosed are methods using the microcatheter for performing local embolization in a small blood vessel feeding a (for example, cancerous) target bodily part, and for delivering infusion agent in a small blood vessel towards such target bodily part. Also disclosed are devices and methods for filtering non-target infusion agent.

Claims

1. ) A kit comprising:

an embolization microcatheter comprising;

(a) a tip having a distal outlet configured for allowing outflow of embolization; and

(b) a filter section comprising a plurality of openings formed around and along a wall of said filter section; and

embolization particles;

wherein the filter section is configured for allowing selective lateral outflow of fluid while preventing outflow of the embolization particles.

2. ) The kit of claim 1, wherein the filter section is more flexible than that of other wall portions of the embolization microcatheter'"'"'s wall.

3. ) The kit of claim 1, wherein the microcatheter has an outer diameter equal to or less than about 1 mm.

4. ) The kit of claim 1, wherein the embolization particles have a diameter ranging from 100 microns to 1500 microns

5. ) The kit of claim 1, wherein a width of each of said plurality of openings is equal to or less than about 100 microns

6. ) The kit of claim 1, further comprising a suspension fluid.

7. ) The kit of claim 6, wherein the embolization particles are suspended in the suspension fluid.

8. ) The kit of claim 1, further comprising a contrast enhancing agent.

9. ) The kit of claim 8, wherein the contrast enhancing agent is suspended in the suspension fluid.

10. ) The kit of claim 8, wherein the contrast enhancing agent comprises lipiodol, iodixanol or iohexol.

11. ) The kit of claim 1, wherein the embolization particles comprises non-spherical particles, or microspheres.

12. ) The kit of claim 1, wherein a total opened cross section of the plurality of openings is equal to or greater than a cross section of the distal outlet.

13. ) The kit of claim 1, wherein the microcatheter is configured as a single integrated structure.

14. ) The kit of claim 1, wherein the plurality of openings is in the form of slits or pores.

15. ) The kit of claim 1, wherein the plurality of openings have a circular or rectangular cross section.

16. ) The kit of claim 1, wherein the plurality openings comprises burst slit configured to open when under a predetermined pressure or force.

17. ) The kit of claim 1, wherein the plurality of openings comprises constantly open slit.