MEMBRANE FOR THE ADSORPTION OF BACTERIA

• US 20190329188A1
• Filed: 11/29/2017
• Published: 10/31/2019
• Est. Priority Date: 11/29/2016
• Status: Abandoned Application

• Current Assignee: Gambro Lundia AB (Baxter International Inc.)
• Original Assignee: Gambro Lundia AB (Baxter International Inc.)
• Inventors: MALARD, Benjamin, PHILIPPE, Nathalie
• Application Number:
  US16/343,542
• Publication Number:
  US 20190329188A1
• Time in Patent Office: Days
• CPC Class Codes: A61M 1/3672 Means preventing coagulation
• CPC Class Codes: A61M 1/3679 by absorption A61M1/3675 takes precedence
• CPC Class Codes: B01D 2323/38 Graft polymerization
• CPC Class Codes: B01D 2325/12 Adsorbents being present on the surface of the membranes or in the pores
• CPC Class Codes: B01D 2325/14 Membrane materials having negatively charged functional groups
• CPC Class Codes: B01D 2325/16 Membrane materials having positively charged functional groups
• CPC Class Codes: B01D 2325/36 Hydrophilic membranes
• CPC Class Codes: B01D 2325/48 Antimicrobial properties
• CPC Class Codes: B01D 61/243 Dialysis
• CPC Class Codes: B01D 61/28 Apparatus therefor
• CPC Class Codes: B01D 63/021 Manufacturing thereof
• CPC Class Codes: B01D 65/022 Membrane sterilisation
• CPC Class Codes: B01D 67/0088 Physical treatment with compounds, e.g. swelling, coating or impregnation
• CPC Class Codes: B01D 67/0093 Chemical modification
• CPC Class Codes: B01D 67/00931 by introduction of specific groups after membrane formation, e.g. by grafting
• CPC Class Codes: B01D 67/00933 by addition of a layer chemically bonded to the membrane
• CPC Class Codes: B01D 69/02 characterised by their properties
• CPC Class Codes: B01D 69/06 Flat membranes
• CPC Class Codes: B01D 69/08 Hollow fibre membranes manufacture of hollow fibres D01D5/24, D01F1/08
• CPC Class Codes: B01D 69/1071 Woven, non-woven or net mesh
• CPC Class Codes: B01D 71/421 : Polyacrylonitrile
• CPC Class Codes: B01D 71/58 : Other polymers having nitrogen in the main chain, with or without oxygen or carbon only
• CPC Class Codes: B01D 71/82 : characterised by the presence of specified groups, e.g. introduced by chemical after-treatment

Abstract

The present disclosure relates to semipermeable membranes based on acrylonitrile copolymers capable of adsorbing bacteria from fluids, methods of producing such membranes, and devices comprising such membranes.

Claims

1. A device for the removal of bacteria from a liquid, comprising a membrane based on a copolymer prepared from sodium methallylsulfonate and acrylonitrile, having a poly-cationic polymer in colloidal form with a mean particle diameter in the range of from about 10 to about 500 nm grafted to its surface, wherein the surface concentration of the poly-cationic polymer in the colloidal form is in the range of from about 5 mg/m² to less than about 15 mg/m²;

with the proviso that the device does not comprise heparin.

2. The device of claim 1, wherein the membrane is a flat sheet membrane or a plurality of flat sheet membranes.

3. The device of claim 1, wherein the membrane is a plurality of hollow fiber membranes.

4. The device of claim 1, wherein the membrane has a surface area in the range of from about 0.4 m² to about 4.0 m².

5. The device of claim 1, wherein the polycationic polymer is a polyethyleneimine (PEI).

6. A process for manufacturing a device for the removal of bacteria from a liquid, the device comprising a housing defining a first compartment and a second compartment, the two compartments being separated by a membrane, with the proviso that the device does not comprise heparin, the method process comprising the following steps:

a) providing a membrane comprising a copolymer of acrylonitrile and methallylsulfonate;

b) mounting the membrane in the housing;

c) providing a suspension in an aqueous acidic medium containing citric acid and about 0.01 g/l to about 0.2 g/l of a polyethyleneimine (PEI) in colloidal form with a mean particle diameter in the range of from about 10 to about 500 nm, the weight ratio of PEI to citric acid being in the range of from about 0.7 to about 1.3;

d) bringing the suspension into contact with at least a first part of the surface of the membrane.

7. The process of claim 6, wherein step d) is performed by circulating the suspension over at least one of the surfaces of the membrane at a flow rate of from about 50 ml/min to about 500 ml/min for a time period of about 1 minute to about 30 minutes.

8. The process of claim 6, wherein the membrane is a flat sheet membrane or a plurality of flat sheet membranes.

9. The process of claim 6, wherein the membrane is a plurality of hollow fiber membranes.

10. The process of claim 6, wherein the membrane has a surface area in the range of from about 0.4 m² to about 4.0 m².

11. A process for the removal of bacteria from a liquid, the process comprising the step of circulating the liquid through a device for the removal of bacteria from a liquid, comprising a membrane based on a copolymer prepared from sodium methallylsulfonate and acrylonitrile, having a poly-cationic polymer in colloidal form with a mean particle diameter in the range of from about 10 to about 500 nm grafted to its surface, wherein the surface concentration of the poly-cationic polymer in the colloidal form is in the range of from about 5 mg/m² to less than about 15 mg/m²;

with the proviso that the device does not comprise heparin.

12. The process of claim 11, wherein the liquid is selected from the group consisting of water, an aqueous solution, and an aqueous suspension.

13. The process of claim 12, wherein the liquid is a substitution fluid used in hemodiafiltration or hemofiltration.

14. The process of claim 12, wherein the liquid is an aqueous solution or an aqueous suspension.

15. The process of claim 11, wherein the liquid is blood or blood plasma.

16. The process of claim 14, wherein the aqueous solution or the aqueous suspension comprises one or more components selected from the group consisting of drugs, electrolytes, and nutrients.

17. The process of claim 11, wherein the membrane is a flat sheet membrane or a plurality of flat sheet membranes.

18. The process of claim 11, wherein the membrane is a plurality of hollow fiber membranes.

19. The process of claim 11, wherein the membrane has a surface area in the range of from about 0.4 m² to about 4.0 m².

20. The process of claim 11, wherein the polycationic polymer is a polyethyleneimine (PEI).