ACC INHIBITORS AND USES THEREOF

• US 20190330224A1
• Filed: 11/27/2018
• Published: 10/31/2019
• Est. Priority Date: 10/26/2015
• Status: Abandoned Application

• Current Assignee: Gilead Apollo LLC (Gilead Sciences Inc.)
• Original Assignee: Gilead Apollo LLC (Gilead Sciences Inc.)
• Inventors: Ghosh, Shomir, Greenwood, Jeremy Robert, Harriman, Geraldine C., Marcel Leit de Moradei, Silvana
• Application Number:
  US16/201,571
• Publication Number:
  US 20190330224A1
• Time in Patent Office: Days
• CPC Class Codes: A01N 43/90 having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents
• CPC Class Codes: A61P 3/06 Antihyperlipidemics
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: C07D 495/04 Ortho-condensed systems

Abstract

The present invention provides compounds useful as inhibitors of Acetyl CoA Carboxylase (ACC), compositions thereof, and methods of using the same.

Claims

1. A compound of formula I or II:

2. The compound of claim 1, wherein R³ is:

3. The compound of claim 2, wherein R³(R⁵)_m, taken together, is:

4. The compound of claim 3, wherein R³(R⁵)_m, taken together, is:

5. The compound of claim 1, wherein R¹ is methyl.

6. The compound of claim 1, wherein R² is Hy.

7. The compound of claim 6, wherein Hy is:

8. The compound of claim 1, wherein L¹ is a covalent bond.

9. The compound of claim 1, wherein L² is ethylene, substituted with 1-2 instances of R⁷.

10. The compound of claim 9, wherein L²(R⁷)_p taken together, is:

11. The compound of claim 10, wherein L²(R⁷)_p taken together, is:

12. The compound of claim 1, wherein R⁴(R⁸)_n, taken together is:

13. The compound of claim 1, wherein the compound is selected from those depicted in Table 1 of the specification.

14. A composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier, adjuvant, or vehicle.

15. A method of inhibiting ACC in a patient in need thereof, comprising administering to said patient the compound of claim 1.

16. A method of inhibiting ACC in a biological sample, comprising contacting the biological sample with the compound of claim 1.

25. A composition for agriculture use comprising a compound of claim 1, or an agriculturally acceptable salt thereof, and an agriculturally acceptable carrier, optionally comprising an adjuvant, optionally comprising one or more additional pesticides, and optionally comprising one or more biological control agents, microbial extracts, natural products, plant growth activators or plant defense agents, or mixtures thereof.

26. A method of controlling agricultural fungal pathogens, the method comprising administering the composition of claim 25 to a plant, a seed or soil.

27. A method of inhibiting ACC in a plant, comprising contacting the plant with the compound of claim 1.

17-24. -24. (canceled)