THIENO[3,2-D]PYRIMIDINES DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS

• US 20190330227A1
• Filed: 05/07/2019
• Published: 10/31/2019
• Est. Priority Date: 07/30/2013
• Status: Active Grant

• Current Assignee: Janssen Sciences Ireland UC (Johnson & Johnson)
• Original Assignee: Janssen Sciences Ireland UC (Johnson & Johnson)
• Inventors: McGowan, David Craig, Raboisson, Pierre Jean-Marie Bernard
• Granted Patent: US 10,822,347 B2
• Time in Patent Office: Days
• CPC Class Codes: A61K 31/519 ortho- or peri-condensed with heterocyclic rings
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61P 37/02 Immunomodulators
• CPC Class Codes: A61P 37/04 Immunostimulants
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07D 495/04 Ortho-condensed systems

Abstract

This invention relates to thieno[3,2-d]pyrimidines derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.

Claims

1. A compound of formula (I)

3. A compound according to claim 1, wherein the compound is selected from the group consisting of:

4. A pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt, tautomer(s), stereo-isomeric forms, or solvate thereof according to claim 1 together with one or more pharmaceutically acceptable excipients, diluents or carriers.

6. A method of treating a disorder in which the modulation of TLR7 and/or TLR8 is involved in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of at least one compound of claim 1.

7. The method of claim 6, wherein the disorder is a viral infection.

2. (canceled)

5. (canceled)