Boron-Containing Small Molecules
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Abstract
This invention relates to compounds useful for treating fungal infections, more specifically topical treatment of onychomycosis and/or cutaneous fungal infections. This invention is directed to compounds that are active against fungi and have properties that allow the compound, when placed in contact with a patient, to reach the particular part of the skin, nail, hair, claw or hoof infected by the fungus. In particular the present compounds have physiochemical properties that facilitate penetration of the nail plate.
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Citations
39 Claims
- 1. A compound having a structure according to Formula I:
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4. A pharmaceutical formulation comprising:
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(a) a pharmaceutically acceptable excipient; and (b) a compound having a structure according to Formula II; - View Dependent Claims (5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 23, 24, 25, 26, 32, 33, 34, 35, 36, 38)
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39. A method of delivering a compound from the dorsal layer of the nail plate to the nail bed, said method comprising:
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contacting said cell with a compound capable of penetrating the nail plate, under conditions sufficient to penetrate said nail plate, wherein said compound has a molecular weight of between about 100 and about 200 Da; said compound has a log P value of between about 1.0 and about 2.6; said compound has a water solubility greater than about 0.1 mg/mL octanol/saturated water thereby delivering said compound.
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Specification