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ANTI-HSPA5 (GRP78) ANTIBODIES AND USES THEREOF

  • US 20190330318A1
  • Filed: 07/24/2017
  • Published: 10/31/2019
  • Est. Priority Date: 07/25/2016
  • Status: Abandoned Application
First Claim
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1. An isolated antibody or antigen-binding fragment thereof that specifically binds human heat shock protein family A (Hsp70) member 5 (human HSPA5), wherein the antibody or antigen-binding fragment thereof:

  • (i) binds to the same epitope on human HSPA5 as a reference antibody;

    or (ii) competes with the reference antibody to bind to human HSPA5, wherein the reference antibody comprises;

    (a) a heavy chain variable region (VH) comprising VH complementarity determining regions 1, 2, and 3 with the amino acid sequences set forth in SEQ ID NO;

    1, SEQ ID NO;

    2, SEQ ID NO;

    3, respectively, and a light chain variable region (VL) comprising VL complementarity determining regions 1, 2, and 3 with the amino acid sequences set forth in SEQ ID NO;

    4, SEQ ID NO;

    5, and SEQ ID NO;

    6, respectively;

    or(b) a VH comprising VH complementarity determining regions 1, 2, and 3 with the amino acid sequences set forth in SEQ ID NO;

    11, SEQ ID NO;

    12, SEQ ID NO;

    13, respectively, and a VL comprising VL complementarity determining regions 1, 2, and 3 with the amino acid sequences set forth in SEQ ID NO;

    14, SEQ ID NO;

    15, and SEQ ID NO;

    16, respectively.

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