THERMALLY AND DIMENSIONALLY STABILIZED ELECTROSPUN COMPOSITIONS AND METHODS OF MAKING SAME

• US 20190330768A1
• Filed: 05/14/2019
• Published: 10/31/2019
• Est. Priority Date: 01/30/2014
• Status: Active Application

• Current Assignee: Poly-Med, Inc.
• Original Assignee: Poly-Med, Inc.
• Inventors: Taylor, Michael Scott, McCullen, Seth D.
• Application Number:
  US16/411,279
• Publication Number:
  US 20190330768A1
• Time in Patent Office: Days
• CPC Class Codes: D01D 1/02 Preparation of spinning solutions
• CPC Class Codes: D01D 5/003 the material being a polymer solution or dispersion D01D5/0053 takes precedence
• CPC Class Codes: D01F 6/625 derived from hydroxy-carboxylic acids, e.g. lactones
• CPC Class Codes: D01F 6/84 from copolyesters
• CPC Class Codes: D04H 1/435 Polyesters
• CPC Class Codes: D04H 1/728 by electro-spinning electro-spinning methods and apparatus D01D5/0007
• CPC Class Codes: D10B 2331/041 derived from hydroxy-carboxylic acids, e.g. lactones
• CPC Class Codes: D10B 2331/06 polyethers
• CPC Class Codes: D10B 2509/00 Medical; Hygiene
• CPC Class Codes: Y10T 428/249921 Web or sheet containing structurally defined element or component

Abstract

Thermally stable absorbable fiber populations, i.e. fiber populations that do not undergo thermally induced crystallization, can be intermixed with thermally unstable fibers to yield a stabilizing effect without altering morphological properties of a fiber system. Via this, one may minimize thermally induced shrinkage and maintain physical properties of electrospun materials in the as-formed state.

Claims

1. A thermally stable electrospun material comprising;

at least two independent fiber populations;

a major fiber component comprising at least one thermally unstable species;

a minor fiber component comprising at least one thermally stable species;

and

wherein the major and minor fiber components are co-mingled and distributed throughout the electrospun material;

wherein the thermally stable species comprises 13% to up to 50% percent of the thermally stable electrospun material; and

wherein the material exhibits limited macroscopic changes in physical and mechanical properties when exposed to thermal or mechanical stress.

2. The thermally stable electrospun material of claim 1, wherein the thermally stable species comprises a bioabsorbable polyether-ester.

3. The thermally stable electrospun material of claim 2, wherein the bioabsorbable polyether-ester comprises poly(para-dioxanone).

5. The thermally stable electrospun material of claim 1, wherein the thermally unstable species comprises a bioabsorbable polyester.

6. The thermally stable electrospun material of claim 5, wherein the bioabsorbable polyester is a copolymer derived from cyclic monomers selected from the group consisting of glycolide, L-lactide, ε

-caprolactone, para-dioxanone, trimethylene carbonate or mixtures thereof.

7. The thermally stable electrospun material of claim 6, wherein the bioabsorbable polyester is a copolymer of glycolide and L-lactide.

8. The thermally stable electrospun material of claim 7, wherein the copolymer of glycolide and lactide has a monomer ratio of glycolide from 80 to 95 and lactide from 20 to 5.

4. (canceled)

9. A multiple fiber population electrospun fabric comprising:

at least two fiber populations;

wherein at least one fiber population is a thermally stable polyetherester that comprises at least 13% percent of the thermally stable electrospun material;

wherein at least one fiber population is a thermally unstable bioabsorbable polyester;

wherein the at least two fiber populations are dispersed throughout the three dimensional structure of the multiple fiber electrospun fabric; and

wherein the multiple fiber electrospun fabric mimics the fibrous topography of the extracellular matrix.

12. The multiple fiber population electrospun fabric of claim 9, wherein the thermally stable polyether-ester comprises poly(para-dioxanone).

13. The multiple fiber population electrospun fabric of claim 9, wherein the thermally unstable bioabsorbable polyester comprises a poly(L-lactide-coglycolide) copolymer.

14. The multiple fiber population electrospun fabric of claim 9, wherein pore size of the multiple fiber population electrospun fabric is maintained after exposure of temperatures of up to 50°

C.

15. The multiple fiber population electrospun fabric of claim 9, wherein the thermally unstable bioabsorbable polyester is a copolymer derived from cyclic monomers selected from the group consisting of glycolide, L-lactide, ε

-caprolactone, para-dioxanone, trimethylene carbonate or mixtures.

10. (canceled)

11. (canceled)

16. A method of forming a fiber mesh comprising:

dissolving a bioabsorbable polyester in a solvent;

dissolving a polyether-ester in a second solvent;

electrospinning the two solutions in an intermixed fashion onto a substrate to form a fiber mesh; and

wherein the bioabsorbable polyester and polyether-ester are dispersed throughout the three dimensional structure of the fiber mesh;

wherein the polyether-ester comprises from 13% to 50% of the fiber mesh.

17. The method of claim 16, wherein the bioabsorbable polyester is a copolymer derived from cyclic monomers selected from the group consisting of glycolide, L-lactide, ε

-caprolactone, para-dioxanone, trimethylene carbonate or mixtures thereof.

18. The method of claim 17 wherein the bioabsorbable polyester comprises a poly(L-lactide-co-glycolide) copolymer.

19. The method of claim 16 wherein the polyether-ester comprises poly(para-dioxanone).

20. (canceled)

21. (canceled)