BLOOD ANALYSIS METHOD, BLOOD ANALYZER, AND NON-TRANSITORY COMPUTER READABLE MEDIUM

• US 20190331659A1
• Filed: 04/16/2019
• Published: 10/31/2019
• Est. Priority Date: 04/26/2018
• Status: Active Grant

• Current Assignee: Sysmex Corporation, University of Yamanashi
• Original Assignee: Sysmex Corporation
• Inventors: Suzuki, Takeshi, Komiyama, Yutaka, Kurono, Hiroshi, Shinohara, Sho, Satoh, Kaneo, Kazama, Fuminori, Shimada, Yugo
• Granted Patent: US 11,268,949 B2
• Time in Patent Office: Days
• CPC Class Codes: G01N 2021/1736 with two or more light sources
• CPC Class Codes: G01N 2021/755 Comparing readings with/without reagents, or before/after reaction
• CPC Class Codes: G01N 2021/7783 Transmission, loss
• CPC Class Codes: G01N 2035/00356 Holding samples at elevated temperature (incubation)
• CPC Class Codes: G01N 2035/0097 monitoring reactions as a function of time
• CPC Class Codes: G01N 2035/0443 for reagents
• CPC Class Codes: G01N 2035/0444 for cuvettes or reaction vessels
• CPC Class Codes: G01N 21/3151 using two sources of radiation of different wavelengths G01N21/33 - G01N21/39 take precedence
• CPC Class Codes: G01N 21/75 Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated systems in which material is burnt in a flame or plasma G01N21/72, G01N21/73
• CPC Class Codes: G01N 21/82 producing a precipitate or turbidity
• CPC Class Codes: G01N 33/4905 Determining clotting time of blood by chemical methods G01N33/86, C12Q1/56
• CPC Class Codes: G01N 33/86 involving blood coagulating time or factors, or their receptors

Abstract

A blood analysis method comprising, acquiring optical information which changes over time from a mixed liquid of a blood sample and a reagent for coagulation time measurement after mixing the blood sample and the reagent, and acquiring information related to a coagulation time and information related to a number of platelets in the blood sample based on the acquired optical information.

Claims

1. A blood analysis method comprising:

acquiring optical information which changes over time from a mixed liquid of a blood sample and a reagent for coagulation time measurement after mixing the blood sample and the reagent; and

acquiring information related to a coagulation time and information related to a number of platelets in the blood sample based on the acquired optical information.

2. The blood analysis method according to claim 1, wherein

the information related to the number of platelets in the blood sample is acquired based on the optical information at an end stage of a coagulation reaction of the blood sample among the acquired optical information.

3. The blood analysis method according to claim 1, further comprising

detecting a coagulation end point from the acquired optical information, wherein

the information related to the number of platelets in the blood sample is acquired based on the optical information in a predetermined time range including a timing after the coagulation end point.

4. The blood analysis method according to claim 1, wherein

the information related to the number of platelets in the blood sample includes the number of platelets or information related to necessity of additional treatment on the blood sample.

5. The blood analysis method according to claim 1, wherein

the optical information is acquired based on a first measurement relating to the measurement of coagulation time;

and

the information related to the number of platelets in the blood sample includes information on an influence on a second measurement that is different from the first measurement.

6. The blood analysis method according to claim 3, further comprising

acquiring an index value indicating a change of state of the optical information based on the optical information in the predetermined range;

and

the information related to the number of platelets in the blood sample is acquired based on the index value.

7. The blood analysis method according to claim 6, wherein

the index value is a change rate or a change amount of the optical information within the predetermined time range.

8. The blood analysis method according to claim 7, wherein

the change rate or the change amount is acquired based on the optical information at a start point and an end point of the predetermined time range.

9. The blood analysis method according to claim 6, wherein

information based on a level of the number of platelets in the blood sample is acquired as the information related to the number of platelets in the blood sample by comparing the index value with one or more preset first reference values.

10. The blood analysis method according to claim 6, wherein

a platelet count in the blood sample is acquired as the information related to the number of platelets in the blood sample based on the index value.

11. The blood analysis method according to claim 10, wherein

information indicating a correlation between the index value and the platelet count is used to obtain the platelet count in the blood sample from the index value.

12. The blood analysis method according to claim 10, further comprising:

acquiring information related to level of the platelet count in the blood sample as the information related to the number of platelets in the blood sample by comparing the platelet count in the blood sample with one or more preset second reference values.

13. The blood analysis method according to claim 10, wherein

information suggesting a presence of measurement items affected by platelets in the blood sample or information regarding a necessity of additional treatment of the blood sample is acquired as the information related to the number of platelets in the blood sample based on the number of platelets in the blood sample.

14. The blood analysis method according to claim 1, wherein

the information related to the number of platelets in the blood sample is displayed on a display means.

15. The blood analysis method according to claim 1, wherein

the optical information is acquired in a step of measuring the coagulation time of the blood sample.

16. The blood analysis method according to claim 3, wherein

the coagulation end point is an end point of a time range used for calculating the coagulation time of the blood sample.

17. The blood analysis method according to claim 16, wherein

a start point of the predetermined time range is set after the coagulation end point.

18. The blood analysis method according to claim 17, wherein

a length of the predetermined time range is 5 seconds or more and 10 seconds or less.

19. A blood analyzer comprising:

a measuring unit for irradiating light to a mixed liquid in which a blood sample and a reagent for coagulation time measurement are mixed, and for detecting light generated from the mixed liquid; and

a processing unit for processing a result detected by the measuring unit;

wherein the processing unit

acquires optical information which changes over time from the mixed liquid after mixing the blood sample and the reagent; and

acquires information related to a coagulation time and information related to a number of platelets in the blood sample based on the acquired optical information.

20. A non-transitory computer readable medium storing programs executable by a processor to:

receive optical information which changes over time from a mixed liquid of a blood sample and a reagent for coagulation time measurement after mixing the blood sample and the reagent; and

acquire information related to a coagulation time and information related to a number of platelets in the blood sample based on the acquired optical information.